高压氧联合纳美芬对弥漫性轴索损伤的临床应用效果  

Clinical application effect of hyperbaric oxygen combined with nalmefene on diffuse axonal injury

作　　者：王学建[1] 汪志峰[1] 李峰[2] Xuejian Wang;Zhifeng Wang;Feng Li(Department of Neurosurgery,Affiliated Hospital 2 of Nantong University,Nantong 226001,China;Department of Emergency Ward,Affiliated Hospital 2 of Nantong University,Nantong 226001,China)

机构地区：[1]南通大学第二附属医院神经外科,江苏南通226001 [2]南通大学第二附属医院急诊科,江苏南通226001

出　　处：《中华神经创伤外科电子杂志》2021年第5期301-304,共4页Chinese Journal Of Neurotraumatic Surgery：Electronic Edition

基　　金：南通市科技项目(JC2018101);江苏省中医药科技项目(YB2015113);南通市医学重点人才基金项目(重点03);南通市科技项目(HS12018002);南通市卫生与计划生育委员会科研项目(MA2019003)。

摘　　要：目的探讨高压氧(HBO)联合纳美芬对弥漫性轴索损伤(DAI)患者促醒治疗的临床效果。方法选取南通大学第二附属医院神经外科和急诊科自2012年8月至2019年8月收治的160例DAI患者,按照随机数字表法将患者分为常规治疗组、HBO治疗组、纳美芬治疗组和HBO联合纳美芬治疗组,各40例。随访3个月,采用GOS评分评定治疗效果,比较4组患者的预后良好率。结果HBO联合纳美芬治疗组的预后良好率较常规治疗组有所提高,差异有统计学意义(P<0.05)。结论HBO联合纳美芬对DAI昏迷患者能促进意识恢复,加速苏醒,改善生活状态。Objective To study the clinical application effect of hyperbaric oxygen(HBO)combined with nalmefene on wake-promoting therapy in patients with diffuse axonal injury(DAI).Methods A total of 160 patients with DAI admitted to the Neurosurgery and Emergency Department of Affiliated Hospital 2 of Nantong University from August 2012 to August 2019 were randomly divided into routine treatment group,HBO treatment group,nalmefene treatment group and HBO combined with nalmefene treatment group,with 40 cases in each group.The patients were followed up for 3 months.The treatment effect was evaluated by GOS score,and the good prognosis rate of 4 groups was compared.Results The good prognosis rate of HBO combined with nalmefene treatment group was higher than in routine treatment group,the difference was statistically significant(P<0.05).Conclusion HBO combined with nalmefene could promote the recovery of consciousness,accelerate waking up and improve their living condition of the patients with a DAI coma.

关 键 词：弥漫性轴索损伤 高压氧 纳美芬 昏迷 促醒 

分 类 号：R651.15[医药卫生—外科学]