利拉鲁肽对肥胖T2DM患者促炎-抗炎系统及左心舒张功能的影响  

Effects of Liraglutide on Pro-inflammatory-anti-inflammatory System and Left Ventricular Diastolic Function in Obese T2DM Patients

作　　者：王晓洲[1] 吴仰帆[1] 栾晓军[1] WANG Xiao-zhou;WU Yang-fan;LUAN Xiao-jun(Department of Endocrinology,Foshan First People's Hospital,Foshan 528000,Guangdong,China)

机构地区：[1]佛山市第一人民医院内分泌科,广东佛山528000

出　　处：《医学信息》2021年第22期145-147,共3页Journal of Medical Information

基　　金：佛山市自筹经费类科技计划项目(编号:2018AB003081)。

摘　　要：目的观察利拉鲁肽对肥胖2型糖尿病(T2DM)患者促炎-抗炎系统、左心舒张功能的影响。方法选择2019年10月-2020年10月我院诊治的40例肥胖T2DM患者作为研究对象,采用随机抽签法分为对照组和观察组,各20例。对照组予以二甲双胍治疗,观察组在对照组基础上联合利拉鲁肽治疗,比较两组血糖指标[空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2h血糖(2hPG)]、促炎因子[白介素-6(IL-6)、高敏-C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)]、抗炎因子[白介素-4(IL-4)、转化生长因子β1(TGF-β1)]、左心舒张功能指标[二尖瓣环处舒张早期最大运动速度(Em)、舒张早期最大峰值速度/舒张晚期最大峰值速度(E/A)、二尖瓣环处舒张晚期最大运动速度(Am)]及不良反应发生情况。结果观察组FPG、2hPG、HbA1c低于对照组(P<0.05)。观察组IL-6、hs-CRP、TNF-α低于对照组,IL-4、TGF-β1高于对照组(P<0.05)。观察组Em、E/A高于对照组,Am低于对照组(P<0.05)。观察组不良反应率为20.00%,与对照组10.00%比较,差异无统计学意义(P>0.05)。结论利拉鲁肽能可降低肥胖T2DM患者血糖水平,维持促炎-抗炎系统平衡,改善左心舒张功能,且应用安全可靠。Objective To observe the effect of liraglutide on the pro-inflammatory-anti-inflammatory system and left ventricular diastolic function in obese type 2 diabetes mellitus(T2DM)patients.Methods Forty obese patients with T2DM who were treated in our hospital from October 2019 to October 2020 were selected as subjects.They were randomly divided into control group and observation group,with 20 cases in each group.The control group was treated with metformin,and the observation group was treated with liraglutide on the basis of the control group.The blood glucose indexes[fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),postprandial 2 h blood glucose(2 hPG)],pro-inflammatory factors[interleukin-6(IL-6),high sensitivity-C reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)],anti-inflammatory factors[interleukin-4(IL-4),transforming growth factor-β1(TGF-β1)],left ventricular diastolic function indexes[maximum early diastolic velocity(Em),maximum early diastolic velocity/maximum late diastolic velocity(E/A),maximum late diastolic velocity(Am)at mitral annulus]and adverse reactions were compared between the two groups.Results The levels of FPG,2hPG and HbA1c in the observation group were lower than those in the control group(P<0.05).The levels of IL-6,hs-CRP and TNF-αin the observation group were lower than those in the control group,while IL-4 and TGF-β1 were higher than those in the control group(P<0.05).Em and E/A in the observation group were higher than those in the control group,and Am was lower than that in the control group(P<0.05).The adverse reaction rate of the observation group was 20.00%,which was compared with 10.00%of the control group,the difference was not statistically significant(P>0.05).Conclusion Liraglutide can reduce the blood glucose level of obese T2DM patients,maintain the balance of pro-inflammatory and anti-inflammatory system,improve left ventricular diastolic function,and is safe and reliable.

关 键 词：利拉鲁肽 2型糖尿病 促炎-抗炎系统 左心舒张功能 

分 类 号：R587.1[医药卫生—内分泌]