CD81,a new actor in the development of preeclampsia  

作　　者：Honglei Duan Yali Hu 

机构地区：[1]Department of Obstetrics and Gynecology,Affiliated Drum Tower Hospital,Medical School of Nanjing University,Nanjing,China

出　　处：《Cellular & Molecular Immunology》2021年第8期2061-2061,共1页中国免疫学杂志（英文版）

基　　金：This study was supported by grants from the National Key R&D Program of China(2018YFC1004404);National Natural Science Foundation of China(81771526).

摘　　要：CD81 is a widely expressed transmembrane protein that provides a scaffold for signaling molecules and orchestrates interactions among membrane-associated proteins to initiate signaling cascades related to cell migration,adhesion,and fusion1.CD81 exerts a wide range of regulatory effects on immune cells.In B cells,CD81 facilitates the assembly of CD19-CR2/CD21 and B-cell receptor complexes at tetraspanin-enriched signaling microdomains,lowering the threshold dose of antigen required to trigger B-cell clonal expansion and antibody production.

关 键 词：CD81 enriched CLAMP 

分 类 号：R392[医药卫生—免疫学]