欣通胶囊对急性心肌梗死犬心肌细胞能量代谢的影响  

Effects of the Xintong capsules on energy metabolism of myocardial cells in dogs with acute myocardial infarction

作　　者：武爽 Wu Shuang

机构地区：[1]齐齐哈尔医学院,黑龙江齐齐哈尔161000

出　　处：《中医临床研究》2021年第22期39-42,共4页Clinical Journal Of Chinese Medicine

摘　　要：目的:研究欣通胶囊对冠状动脉结扎诱发犬急性心肌梗死心肌细胞能量代谢的影响,为临床开发新药提供实验依据。方法:采用结扎犬冠状动脉的造模方法,建立急性心肌缺血模型,观察其对模型犬血浆中钾离子(K^(+))、钙离子(Ca^(2+))、乳酸、游离脂肪酸的影响,观察欣通胶囊对急性心肌缺血心肌细胞的保护作用。结果:欣通胶囊可以降低模型犬血浆中钾离子浓度、升高钙离子浓度(P <0.05),保护Na^(+)-K^(+)-三磷酸腺苷酶和Ca^(2+)-三磷酸腺苷酶的活性,从而使钾离子和钙离子能正常的转运。欣通胶囊能降低乳酸、游离脂肪酸含量(P <0.05),改善缺血缺氧状态,使心肌正常利用游离脂肪酸供能,减少糖无氧酵解,保护心肌细胞膜三磷酸腺苷酶活性,使其保持完整。结论:欣通胶囊对急性心肌梗死犬心肌细胞能量代谢有一定的保护作用。Objective:To study the effect of the Xintong capsules(欣通胶囊) on the energy metabolism of myocardial cells in dogs with acute myocardial infarction induced by coronary artery ligation,and to provide experimental evidence for clinical development of new drugs.Methods:The model method of ligating the coronary arteries of dogs was used to establish an acute myocardial ischemia model.The effects of the Xintong capsules on K^(+),Ca^(2+),lactic acid and free fatty acids in the plasma of model dogs were observed.The protective effect of the Xintong capsules on acute myocardial ischemia myocardial cells was observed.Results:The Xintong capsules can reduce the potassium ion concentration and increase the calcium ion concentration in the model dog’s plasma(P<0.05),protect the activity of Na^(+)-K^(+)-adenosine triphosphate and Ca^(2+)-adenosine triphosphate,so that potassium ions and calcium ions can be transported normally.The Xintong capsules can reduce the content of lactic acid and free fatty acid(P<0.05),improve the ischemia and hypoxia state,make the myocardium use free fatty acid for energy normally,reduce the anaerobic glycolysis of sugar,protect the activity of myocardial cell membrane adenosine triphosphate,and keep it intact.Conclusion:The Xintong capsules has a certain protective effect on the energy metabolism of myocardial cells in dogs with acute myocardial infarction.

关 键 词：欣通胶囊 急性心肌梗死 能量代谢 

分 类 号：R542.22[医药卫生—心血管疾病]