^(18)F-FDG PET/MRI评估宫颈癌大小、分化程度、肌层浸润深度和周围组织受累  

^(18)F-FDG PET/MRI evaluation on the size,differentiation degree,myometrial invasion depth and surrounding tissue involvement of cervical cancer

作　　者：刘红红 刘家金 王瑞民 徐白萱 姚树林 LIU Honghong;LIU Jiajin;WANG Ruimin;XU Baixuan;YAO Shulin(Department of Nuclear Medicine,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]中国人民解放军总医院第一医学中心核医学科,北京100853

出　　处：《中国医学影像技术》2021年第11期1619-1623,共5页Chinese Journal of Medical Imaging Technology

摘　　要：目的观察^(18) F-FDG PET/MRI病灶最大标准摄取值(SUV max)和最小表观弥散系数(ADC min)评估宫颈癌大小、分化程度、肌层浸润深度和累及周围组织的价值。方法回顾性分析45例宫颈癌患者的PET/MRI,根据术后病理将其分为中-高分化组(n=20)和低分化组(n=25);测量病灶长径和短径,并计算病灶平均径、SUV max及ADC min,观察SUV max和ADC min评估宫颈癌大小、分化程度、肌层浸润深度及周围组织受累的效能。结果45例宫颈癌病灶平均径为(27.67±11.53)mm,中-高分化组病灶平均径[(27.68±2.71)mm]与低分化组[(27.67±2.26)mm]差异无统计学意义(P>0.05)。MRI显示15例宫颈肌层浸润深度≤1/2肌层,其中11例与病理结果一致;30例浸润深度>1/2肌层,其中28例与病理结果一致;MRI与病理符合率为86.67%(39/45)。病理结果显示10例宫颈癌累及子宫体、3例累及子宫旁脂肪组织、8例累及阴道、3例累及附件;PET/MRI检出率分别为80.00%(8/10)、66.67%(2/3)、75.00%(6/8)和66.67%(2/3)。宫颈癌SUV max与其平均径呈中度正相关(r=0.536,P<0.01),且中-高分化组SUV max与低分化组差异无统计学意义(P>0.05)。宫颈癌ADC min与其平均径呈中度负相关(r=-0.525,P<0.01),且中-高分化组ADC min[(0.744±0.122)×10^(-3) mm^(2)/s]明显高于低分化组[(0.654±0.132)×10^(-3) mm^(2)/s](P<0.05)。结论^(18) F-FDG PET/MRI观察病灶SUV max和ADC min有助于评估宫颈癌大小、分化程度、肌层浸润深度及周围组织受累,尤以ADC min价值较高。Objective To observe the maximum standard uptake value(SUV_(max))and the minimum apparent diffusion coefficient(ADC_(min))on ^(18)F-FDG PET/MRI for evaluating the size,differentiation degree,myometrial invasion depth and surrounding tissue involvement of cervical cancer.Methods PET/MRI of 45 patients with cervical cancer were retrospectively analyzed.The patients were divided into medium-high differentiation group(n=20)and low differentiation group(n=25)according to postoperative pathology.The long and short diameter of cervical cancers were measured,and the mean diameter,SUV_(max) and ADC_(min) were calculated,the value of SUV_(max) and ADC_(min) for evaluating the size,degree of differentiation,depth of myometrial invasion and surrounding tissue involvement of cervical cancer were observed.Results The mean diameter of 45 cervical cancer lesions was(27.67±11.63)mm,and there was no significant difference of the mean diameter between medium-high differentiation group([27.68±2.71]mm)and low differentiation group([27.67±2.26]mm,P>0.05).MRI showed myometrial invasion depth of cervical cancer≤1/2 myometrium in 15 cases,including 11 cases being consistent with pathological findings,while>1/2 myometrium 30 cases,including 28 cases being consistent with pathological findings,and the coincidence rate of pathology and MRI was 86.67%(39/45).Pathological results showed involved uterine body in 10 cases,involved parauterine adipose tissue in 3 cases,involved vagina in 8 cases and involved accessories in 3 cases,and MRI detection rate of the above involvements was 80.00%(8/10),66.67%(2/3),75.00%(6/8)and 66.67%(2/3),respectively.Moderately positive correlation was detected between SUV_(max) and the mean diameter of cervical cancer(r=0.536,P<0.01),while there was no significant difference of SUV_(max) between groups(P>0.05).Moderately negative correlation was found between ADC_(min)and mean diameter of cervical cancer(r=-0.525,P<0.01),and ADC_(min) of medium-high differentiation group([0.744±0.122]×10^(-3) mm^(2)/s)was si

关 键 词：子宫颈肿瘤 正电子发射断层显像 磁共振成像 18F氟脱氧葡萄糖 

分 类 号：R711.74[医药卫生—妇产科学] R445.2[医药卫生—临床医学]