血清PGR水平与营养代谢指标相关性研究  

Correlation between serum PGR level and nutritional metabolism index

作　　者：吴光勤 聂锦山[1] 陈龙 龚辰 杭程 朱建新[1] WU Guang-qin;NIE Jin-shan;CHEN Long;GONG Chen;HANG Cheng;ZHU Jian-xin(Department of Gastroenterology,Taicang Affiliated Hospital of Scoochow University,215400 Suzhou,China)

机构地区：[1]苏州大学附属太仓医院消化内科,江苏太仓215400

出　　处：《临床消化病杂志》2021年第5期330-333,共4页Chinese Journal of Clinical Gastroenterology

基　　金：2018年度江苏卫生健康职业学院院级科研项目(No:JKFY201817)。

摘　　要：[目的]研究血清胃蛋白酶原(pepsinogen,PG)Ⅰ与PGⅡ的比值(PGⅠ/Ⅱratio,PGR)与营养代谢指标的相关性。[方法]选取2019-08-2019-12期间在我院体检者217例,根据血清PGR水平,分为PGR≤3组(106例)及PGR>3组(111例)。分析2组年龄、性别、体质指数、血压、血糖、血红蛋白、血总蛋白、白蛋白、铁蛋白、谷丙转氨酶、谷草转氨酶、尿酸、肌酐、三酰甘油、低密度脂蛋白指标与PGR之间的关系。[结果]PGR≤3组与PGR>3组间无明显性别差异,高龄者PGR水平明显偏低。PGR≤3组三酰甘油、血清白蛋白、铁蛋白水平明显降低。白蛋白、血红蛋白、铁蛋白、三酰甘油水平与PGR水平呈正相关,而血尿酸与PGR水平呈负相关。Logistic回归分析显示年龄、三酰甘油、白蛋白及铁蛋白水平与PGR独立相关。[结论]低PGR水平是反映营养及代谢状态的一种标志,对于低PGR水平者,应特别重视血清铁、蛋白及脂质代谢状态。[Objective]To investigate the correlation between PGR(PGⅠ/Ⅱratio)and nutritional metabolism indexes.[Methods]Subjects who underwent a health screening test from August 2019 to December2019 were collected.The subjects were grouped into PGR≤3 and PGR>3 according to the level of PGR.We finally recruited 106 subjects whose PGR≤3,and 111 participants characterized by PGR>3.The relationship between PGR and age,sexes,BMI(body mass index),blood pressure,blood glucose,hemoglobin,total blood protein,albumin,ferritin,Alanine transferase,Aspartate aminotransferase,uric acid,creatinine,triglyceride,as well as low-density lipoprotein were analyzed.[Results]There was no significant difference in gender between the two groups.The low level of PGR tended to be older.The levels of triglyceride,serum albumin and ferritin in PGR≤3 groups were significantly decreased,while the age was significantly increased.Albumin,hemoglobin,ferritin and triglyceride levels were positively correlated with PGR,while uric acid was negatively correlated with PGR.Multivariate logistic regression analysis showed that triglyceride,albumin and ferritin levels were independently correlated with PGR.[Conclusion]Low PGR is a marker of nutritional and metabolic status.We shoud pay attention to the nutritional and metabolic status of subjects with low PGR levels,especially the status of iron,protein and lipid metabolism.

关 键 词：血清胃蛋白酶原 血清胃蛋白酶原Ⅰ与血清胃蛋白酶原Ⅱ的比值 营养代谢 

分 类 号：Q55[生物学—生物化学]