干扰素-ε研究进展  

Research Progress of Interferon-ε

作　　者：张海玲 廉士珍[2] 张东亮[2] 白雪[2] 章沙沙[1] 张蕾 李伟[3] 刘方圆 王菡 胡博[2] 卢士英[1] ZHANG Hailing;LIAN Shizhen;ZHANG Dongliang;BAI Xue;ZHANG Shasha;ZHANG Lei;LI Wei;LIU Fangyuan;WANG Han;HU Bo;LU Shiying(Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun 130062, China;Key Laboratory of Special Animal Epidemic Disease, Ministry of Agriculture, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China;Jilin Teyan Biotechnological Co. Ltd, Changchun 130122, China)

机构地区：[1]吉林大学人兽共患病研究所人兽共患病教育部重点实验室,长春130062 [2]中国农业科学院特产研究所农业部特种经济动物疫病重点实验室,长春130112 [3]吉林特研生物技术有限责任公司,长春130122

出　　处：《畜牧兽医学报》2021年第11期3023-3029,共7页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(32072943);中国农业科学院科技创新工程(CAAS-ASTIP-2016-ISAPS)。

摘　　要：干扰素-ε(IFN-ε)是新发现的一种Ⅰ型干扰素(IFNs),是由多种细胞分泌的一类细胞因子,其本质是一种糖蛋白,可间接发挥抗病毒、免疫调节和抗肿瘤的生物学活性。但与其他Ⅰ型干扰素不同,IFN-ε的产生不需要病毒诱导,其由黏膜上皮细胞组成型表达,并受激素调节,在黏膜免疫中具有重要作用。目前相关研究报道较少,本文就人和不同动物IFN-ε的起源、体内分布规律,以及对生殖系统的保护、神经系统的调节及抗病毒等研究进展进行综述,以便进一步了解和开发新型干扰素。Interferon-epsilon(IFN-ε)is a novel type I interferons(IFNs),which is also a type of cytokines secreted by varieties of cells.It is a glycoprotein,which can exert antiviral,immunoregulatory and anti-tumor biological activities.However,unlike other type I IFNs,IFN-εis constitutively expressed by mucous epithelial cell and regulated by hormones without virus induction.IFN-εplays an important role in mucosal immunity.At present,there are few reports on related studies.In this paper,we reviewed the research progress of IFN-εorigin of human and different animals,distribution in vivo,protection of reproductive system,regulation of nervous system and antiviral effect,to further understand and develop new IFNs reagent.

关 键 词：干扰素-ε 细胞因子 组成型表达 抗病毒活性 

分 类 号：S852.4[农业科学—基础兽医学]