HCgp-39、CRP、IL-2表达水平与老年慢性阻塞性肺疾病急性发作的关联  

The relationship between the expression level of HCgp-39,CRP,IL-2and the risk of acute attack in elderly patients with chronic obstructive pulmonary disease

作　　者：赵静 程青 钟强[2] ZHAO Jing;CHENG Qing;ZHONG Qiang(Department of Emergency,Taikang Tongji(Wuhan)Hospital,Wuhan,Hubei 430050,China;Department of Emergency,Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan,Hubei 430000,China)

机构地区：[1]泰康同济(武汉)医院急诊科,湖北武汉430050 [2]华中科技大学同济医学院附属同济医院急诊科,湖北武汉430000

出　　处：《国际检验医学杂志》2021年第22期2795-2798,共4页International Journal of Laboratory Medicine

摘　　要：目的探讨血清人类软骨糖蛋白-39(HCgp-39)、C反应蛋白(CRP)及白细胞介素(IL)-2表达水平与老年慢性阻塞性肺疾病(COPD)急性发作的关联。方法将120例老年COPD患者根据是否出现急性发作分为急性组(50例)和非急性组(70例),收集两组患者的一般资料,测定其血清HCgp-39、CRP、IL-2水平,并采用Logistic回归筛选出影响COPD急性发作的因素。结果急性组血清HCgp-39、CRP和IL-2水平高于非急性组(P<0.05),Logistic回归分析显示,HCgp-39水平升高(OR=2.45,95%CI:1.61~4.02)、年龄增加(OR=1.68,95%CI:1.42~1.91)、体质量指数(BMI)降低(OR=0.77,95%CI:0.69~0.85)以及病程>5年(OR=1.82,95%CI:1.47~2.20)为老年COPD急性发作的危险因素。结论老年COPD患者急性发作期血清HCgp-39、CRP以及IL-2的表达水平均明显升高,血清HCgp-39水平升高、年龄增加、BMI减低以及病程>5年为老年COPD急性发作的危险因素。Objective To investigate the relationship between serum HCgp-39,C-reactive protein(CRP),interleukin(IL)-2 expression and acute onset of elderly chronic obstructive pulmonary disease(COPD).Methods 120 elderly COPD patients were divided into acute onset group and non-acute onset group according to whether the attack was the occurrence of acute onset.The patient′s basic information were collected,the serum levels of HCgp-39,CRP and IL-2 were determined,and the factors affecting the acute onset of COPD were screened out using the Logistic regression analysis.Results The levels of serum HCgp-39,CRP and IL-2 in the acute onset group were significantly higher than those in the non-acute onset group.High HCgp-39 level(OR=2.45,95%CI:1.61-4.02),old age(OR=1.68,95%CI:1.42-1.91),low body mass index(BMI)(OR=0.77,95%CI:0.69-0.85),and disease course>5 years(OR=1.82,95%CI:1.47-2.20)were risk factors for acute onset of COPD in the elderly patients.Conclusion The expression levels of serum HCgp-39,CRP and IL-2 in elderly COPD patients are significantly increased during acute episode,high serum HCgp-39 level,old age,low BMI,and disease course>5 years are risk factors for acute onset of COPD in the elderly,which should be prevented and controlled clinically.

关 键 词：人类软骨糖蛋白-39 老年 慢性阻塞性肺疾病 

分 类 号：R563[医药卫生—呼吸系统]