磷酸钙/聚甲基丙烯酸甲酯复合骨水泥与聚甲基丙烯酸甲酯骨水泥生物力学性能的对照  

Comparison of biomechanical properties of calcium phosphate/polymethyl methacrylate composite bone cement and polymethyl methacrylate bone cement

作　　者：李胜凯 李涛[2] 魏超[2] 时明 Li Shengkai;Li Tao;Wei Chao;Shi Ming(The First Clinical Medical College of Binzhou Medical College,Binzhou 256600,Shandong Province,China;Zibo Central Hospital,Zibo 255000,Shandong Province,China)

机构地区：[1]滨州医学院第一临床医学院,山东省滨州市256600 [2]淄博市中心医院,山东省淄博市255000

出　　处：《中国组织工程研究》2022年第16期2461-2466,共6页Chinese Journal of Tissue Engineering Research

基　　金：2017年无锡市卫生计生科研面上项目(MS201726),项目负责人:赵锡江。

摘　　要：背景:聚甲基丙烯酸甲酯(polymethyl methacrylate,PMMA)是椎体强化运用最多的骨水泥,但目前仍存在弹性模量过大等缺陷。针对如何降低其弹性模量进行骨水泥体外力学测试,对于指导临床具有一定的意义。目的:检测PMMA骨水泥及其添加自固化磷酸钙人工骨后复合骨水泥的抗压强度,评价添加磷酸钙人工骨对PMMA骨水泥弹性模量的影响。方法:将磷酸钙人工骨(0,4,8 g)、PMMA(26 g)加入液相单体,分别制备PMMA(100%)、磷酸钙/PMMA(87%)、磷酸钙/PMMA(76%)骨水泥,分别注入人松质骨标准实验模块内,制备骨质疏松模型,通过标准压缩实验测定各模型的极限抗压强度和弹性模量。将PMMA(100%)、磷酸钙/PMMA(87%)、磷酸钙/PMMA(76%)骨水泥制备成圆柱形的标准骨水泥试件,确定最高固化温度和每个样品达到最高固化温度所需的时间,通过标准压缩实验测定各模型的极限抗压强度和弹性模量。结果与结论:(1)在骨水泥标准试件模型中,磷酸钙/PMMA(87%)组、磷酸钙/PMMA(76%)组的最大抗压缩强度及弹性模量均低于PMMA(100%)组(P<0.05),磷酸钙/PMMA(76%)组的抗压强度低于磷酸钙/PMMA(87%)(P<0.05);磷酸钙/PMMA复合骨水泥的最高固化温度较PMMA骨水泥降低,凝固时间无明显变化。(2)在骨质疏松模型中,磷酸钙/PMMA(87%)组、磷酸钙/PMMA(76%)组的最大抗压强度均低于PMMA(100%)组(P<0.05),磷酸钙/PMMA(76%)组的弹性模量低于磷酸钙/PMMA(87%)组(P<0.05)。(3)结果表明,在PMMA骨水泥中添加磷酸钙可降低弹性模量;在一定范围内,磷酸钙/PMMA复合骨水泥较PMMA骨水泥具有更好的力学和结构特性,且可操控性无明显变化,可用于椎体强化。BACKGROUND:Polymethyl methacrylate(PMMA)is the most widely used bone cement in vertebral body reinforcement,but it still has some defects such as excessive elastic modulus.The in vitro mechanical test of bone cement for how to reduce its elastic modulus has a certain significance for guiding clinical practice.OBJECTIVE:To measure compressive strength of PMMA bone cement and its composite bone cement after adding self-solidifying calcium phosphate artificial bone,and evaluate the effect of adding calcium phosphate artificial bone on the elastic modulus of PMMA bone cement.METHODS:PMMA(100%),calcium phosphate/PMMA(87%)and calcium phosphate/PMMA(76%)bone cement were prepared by adding calcium phosphate artificial bone(0,4,8 g)and PMMA(26 g)to liquid phase monomer,respectively,and injected into the standard experimental module of human cancellous bone to prepare human osteoporosis model.The ultimate compressive strength and elastic modulus of each model were measured by standard compression test.PMMA(100%),calcium phosphate/PMMA(87%)and calcium phosphate/PMMA(76%)bone cement were prepared into cylindrical standard bone cement specimens;the highest curing temperature and the time required for each sample to reach the highest curing temperature were determined;and the ultimate compressive strength and elastic modulus of each model were measured by standard compression test.RESULTS AND CONCLUSION:(1)In the bone cement standard specimen model,the maximum compressive strength and elastic modulus of calcium phosphate/PMMA(87%)group and calcium phosphate/PMMA(76%)group were lower than those of PMMA(100%)group(P<0.05),and the compressive strength of calcium phosphate/PMMA(76%)group was lower than that of calcium phosphate/PMMA(87%)(P<0.05).The maximum curing temperature of calcium phosphate/PMMA composite bone cement was lower than that of PMMA bone cement,and there was no significant change in solidification time.(2)In the osteoporosis model,the maximum compressive strength of calcium phosphate/PMMA(87%)group and calcium ph

关 键 词：骨水泥 生物力学 椎体成形 聚甲基丙烯酸甲酯 自固化磷酸钙人工骨 聚氨酯硬质泡沫 

分 类 号：R459.9[医药卫生—治疗学] R318.01[医药卫生—临床医学]