氧化铁纳米粒子表面处理如何更适应骨缺损的修复  

Surface treatment of iron oxide nanoparticles in bone defect repair

作　　者：马子雨 张云涛[2] 马向瑞 乔鲁卉 郭浩宇 侯玉东 Ma Ziyu;Zhang Yuntao;Ma Xiangrui;Qiao Luhui;Guo Haoyu;Hou Yudong(Binzhou Medical University,Binzhou 256600,Shandong Province,China;Binzhou Medical University Hospital,Binzhou 256600,Shandong Province,China;School of Stomatology,Binzhou Medical University,Yantai 264010,Shandong Province,China)

机构地区：[1]滨州医学院,山东省滨州市256600 [2]滨州医学院附属医院,山东省滨州市256600 [3]滨州医学院口腔医学院,山东省烟台市264010

出　　处：《中国组织工程研究》2022年第16期2570-2575,共6页Chinese Journal of Tissue Engineering Research

基　　金：山东省自然科学基金博士基金(ZR2018BH026),项目负责人:马向瑞;山东省医药卫生科技发展计划面上项目(2017WS231),项目负责人:马向瑞;滨州医学院科研计划与科研启动基金(BY2015KYQD24),项目负责人:马向瑞。

摘　　要：背景:随着纳米技术的进步和发展,纳米颗粒因其纳米材料特性引起了人们的广泛关注,其中氧化铁纳米粒子可应用于电子学、化学、生物医学等领域。目的:探讨在骨缺损修复方面氧化铁纳米粒子表面处理的研究进展。方法:检索Pub Med、万方、中国知网、维普数据库中发表的相关文献,中文检索词为"磁性纳米粒子、氧化铁纳米粒子、表面修饰、表面处理、表面改性、骨缺损、骨修复、骨再生",英文检索词为"IONPS、iron oxide nanoparticles、Surface treatment、surface modification、bone repair、bone regeneration、osteogenesis",查阅2005-2020年收录的相关文章。结果与结论:近年来氧化铁纳米粒子在医学领域的研究越来越广泛,从最初的磁共振成像到后来的药物输送、干细胞治疗、组织修复和热疗等,针对不同的研究目的,对氧化铁纳米粒子的要求侧重点也稍有不同,这就需要对纳米颗粒表面进行不同的处理。针对骨缺损修复,对氧化铁纳米颗粒进行表面处理的物质主要包括有机材料和无机材料,尽管已经取得了一定的突破,但如何控制纳米粒子的尺寸、增加其稳定性及在外加磁场的环境下纳米粒子与细胞间的生物学机制仍需进一步探索。BACKGROUND: With the progress and development of nanotechnology, nano-particles have attracted extensive attention due to their nanomaterial properties, among which ferric oxide nanoparticles can be used in electronics, chemistry, biomedicine and other fields.OBJECTIVE: To discuss the progress of surface treatment of iron oxide nanoparticles in bone defect repair.METHODS: A computer-based search of Pub Med, Wanfang, CNKI, and VIP database was performed for retrieving articles published from 2005 to 2020, and the Chinese search terms were "magnetic nanoparticles, iron oxide nanoparticles, surface modification, surface treatment, surface modification, bone defect, bone repair, bone regeneration". The English search terms were "IONPS, iron oxide nanoparticles, surface treatment, surface modification, bone repair, bone regeneration, osteogenesis".RESULTS AND CONCLUSION: In recent years, iron oxide nanoparticles have been increasingly studied in the medical field, from the initial magnetic resonance imaging, to later drug delivery, stem cell therapy, tissue repair and hyperthermia. For different research purposes, the emphasis of iron oxide nanoparticles is also slightly different, which requires different surface treatments of nanoparticles. For bone defect repair, materials for surface treatment of iron oxide nanoparticles mainly include organic and inorganic materials. Some breakthroughs have been made, but how to control the size of the nanoparticles, increase its stability, and under the additional magnetic field environment, biology mechanism between nanoparticles and cells still need further exploration.

关 键 词：氧化铁纳米粒子 磁性纳米粒子 SPIO 表面改性 表面修饰 骨缺损修复 骨再生 成骨 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学]