自修复水凝胶在骨组织工程中的应用  

Application of self-healing hydrogels in bone tissue engineering

作　　者：付正 李润泽 罗皓天 陈珺 王伟财[1] Fu Zheng;Li Runze;Luo Haotian;Chen Jun;Wang Weicai(Guanghua School of Stomatology,Hospital of Stomatology,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Stomatology,Guangzhou 510055,Guangdong Province,China;Guangdong Provincial Key Laboratory of Orthopedics and Traumatology,First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,Guangdong Province,China)

机构地区：[1]中山大学光华口腔医学院·附属口腔医院,广东省口腔医学重点实验室,广东省广州市510055 [2]中山大学附属第一医院广东省骨科学重点实验室,广东省广州市510080

出　　处：《中国组织工程研究》2022年第16期2590-2595,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(82001005),项目负责人:王伟财;广东省自然科学基金(2018A030310278),项目负责人:王伟财;广州市科技计划(201804010459),项目负责人:王伟财。

摘　　要：背景:自修复水凝胶是具有良好的自修复性和生物相容性的支架材料,在骨组织工程中应用广泛。目的:介绍自修复水凝胶的凝胶化机制和组成成分,总结其在骨组织工程中的应用。方法:由第一作者检索中国知网、万方、维普、Pub Med、Embase和Web of Science数据库2000-2020年发表的相关文献,中文检索关键词为"自修复水凝胶,骨组织工程,骨再生",英文检索关键词为"self-healinghydrogels;bone tissue engineering;bone regeneration",最终选取符合标准的69篇文献进行综述。结果与结论:自修复水凝胶的凝胶化机制有动态共价键、超分子键和多机制交联,自修复水凝胶的组成成分有天然聚合物、合成聚合物和纳米复合材料。目前发现,自修复水凝胶可以通过干细胞递送和支架修饰的方式应用于骨组织工程,但自修复水凝胶在骨组织工程中的应用还存在如何兼顾材料自修复性和机械性能的问题,同时自修复水凝胶较传统水凝胶在骨组织工程应用中表现出优越性的具体机制尚不明确。BACKGROUND: Self-healing hydrogels are scaffold materials with superior self-healing capability and biocompatibility, and are widely used in bone tissue engineering.OBJECTIVE: To introduce the gelatin mechanism and composition of self-healing hydrogels and summarize their applications in bone tissue engineering.METHODS: The first author searched both Chinese and English articles with key words "self-healing hydrogels;bone tissue engineering;bone regeneration" on CNKI, Wanfang, VIP, Pub Med, Embase and Web of Science databases published from 2000 to 2020. Totally 69 eligible articles were selected for review.RESULTS AND CONCLUSION: The gelation mechanisms of self-healing hydrogels include dynamic covalent bonds, supramolecular bonds and multi-mechanism cross-links. Self-healing hydrogels can be composed of natural polymers, synthetic polymers and nanocomposites. Self-healing hydrogels have been found to be applied in bone tissue engineering through scaffold modification as stem cells delivery vehicle. The application of self-healing hydrogels in bone tissue engineering can be broaden by enhancing the mechanical properties of the hydrogel while maintaining its self-healing capability. Additionally, the specific mechanism for better superiority of self-repairing hydrogels over traditional hydrogels in bone tissue engineering is still unclear.

关 键 词：自修复水凝胶 骨组织工程 骨再生 水凝胶 细胞递送 生物活性因子 支架生物功能化 支架材料 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学]