膜式人工肺中空纤维膜材料的改善及发展新方向  

Improvement and new development of hollow fiber membrane materials for membrane artificial lung

作　　者：李雅坤 黑飞龙 Li Yakun;Hei Feilong(Department of Extracoporeal Circulation,Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China)

机构地区：[1]中国医学科学院阜外医院体外循环科,北京市100037

出　　处：《中国组织工程研究》2022年第16期2608-2612,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金面上项目(30570792),项目负责人:黑飞龙。

摘　　要：背景:随着各种优质膜材料的相继出现,选择适宜的膜材料已成为人工肺技术开展的关键。通过物理或化学方法对膜材料表面进行改性处理以制备具有优良血液相容性和高气体交换率等优异性能的复合膜,是当下研究的热点问题。目的:从人工肺的发展过程出发,介绍目前常用的膜材料,并对当下提高膜材料血液相容性的研究成果进行综述,对未来改善膜式人工肺中空纤维膜材料的新方向提出展望。方法:检索Pub Med数据库、CNKI和万方数据库中已发表的与人工肺膜材料有关的文献,并对其进行阅读和筛选。英文检索词为"artificial lung;membrane artificial lung;oxygenator;hollow fiber membrane;polymer;blood compatibility";中文检索词为"人工肺;膜式人工肺;氧合器;中空纤维膜;高分子材料;血液相容性"。结果与结论:近年来,各类可以改善血液相容性的分子不断被研究者用来对膜式人工肺膜材料表面进行改性,肝素、亲水性分子(如聚乙二醇)、两性分子(如磷酰胆碱)等改性膜材料的研究相对比较成熟,已在临床得到广泛应用,其他改良措施(例如表面内皮化、NO释放中空纤维)也逐渐发展起来。然而,目前提高膜材料气体交换能力的研究较少,尤其是在氧合性能方面仍有继续完善优化的空间。未来人工肺膜材料的研究会朝着两个方向发展:一是开发混合型膜材料表面改性涂层,结合各类材料优势达到血液相容性最大化的目的;二是可以通过改善血流动力学、改进制膜工艺、物理或化学改性等方法提高膜材料的气体交换氧合性能及避免发生血浆渗漏。BACKGROUND: With the emergence of various high-quality membrane materials, the selection of suitable membrane materials has become the key to the development of artificial lung technology. The surface modification of membrane materials by physical or chemical methods to prepare composite membranes with excellent performance such as good blood compatibility and high gas exchange rate is a hot topic in current research.OBJECTIVE: Based on the development process of artificial lung, the commonly used membrane materials were introduced, and the research results of improving the blood compatibility of membrane materials were reviewed, and the new direction of improving the hollow fiber membrane materials for artificial lung in the future was proposed.METHODS: The articles related to artificial lung membrane materials published on Pub Med database, CNKI database and Wanfang database were searched, and the articles were read and screened. Key words in English and Chinese were "artificial lung;membrane artificial lung;oxygenator;hollow fiber membrane;polymer;blood compatibility".RESULTS AND CONCLUSION: In recent years, various kinds of molecules that can improve blood compatibility have been used by researchers to improve the surface of membrane materials of membrane artificial lung. Studies on modified membrane materials such as heparin, hydrophilic molecules(such as polyethylene glycol) and amphoteric molecules(such as phosphocholine) are relatively mature and have been widely used in clinical practice. Other improvement measures(such as surface endothelialization, NO release hollow fiber) are also gradually developed. However, there are few studies on improving the gas exchange capacity of membrane materials, and there is still room for further improvement and optimization in oxygenation performance. In the future, the research of artificial lung membrane materials will develop in two directions: one is to develop the surface modified coating of mixed membrane materials to maximize blood compatibility by combining the

关 键 词：人工肺 膜式人工肺 氧合器 中空纤维膜 高分子材料 血液相容性 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学]