周围神经病变与补体C1q肿瘤坏死因子相关蛋白1促炎反应的关系研究  

Study on the relationship between peripheral neuropathy and CTRP1 pro-inflammatory response

作　　者：辛雅萍[1] 李天天 祝艺涵 张琦 XIN Yaping;LI Tiantian;ZHU Yihan;ZHANG Qi(The Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450003,China)

机构地区：[1]郑州大学第二附属医院,河南郑州450003

出　　处：《中国实用神经疾病杂志》2021年第17期1482-1488,共7页Chinese Journal of Practical Nervous Diseases

基　　金：河南省医学科技攻关项目(编号:201702094);河南省科技攻关项目(编号:182102310591)。

摘　　要：目的探讨补体C1q肿瘤坏死因子相关蛋白1(CTRP1)促炎反应在糖尿病合并周围神经病变(DPN)发生中的作用。方法选取2017-08—2020-11在郑州大学第二附属医院就诊的单纯2型糖尿病(T2DM)患者58例(T2DM组),DPN患者58例(DPN组)和60例健康体检者(HC组)为研究对象。采用酶联免疫吸附试验(ELISA)检测血清中脂肪因子CTRP1,炎症相关因子TNF-α、IL-1β、IL-6及炎症趋化因子MCP-1水平。结果DNP组空腹血糖和糖化血红蛋白均显著高于T2DM组,且DNP组CTRP1、TNF-α和MCP-1也显著高于T2DM组。Pearson相关性分析和Logistic回归分析显示,CTRP1、TNF-α和MCP-1与DNP的发生密切相关,且是DPN的独立影响因素。而CTRP1相关性分析显示,血清CTRP1水平与TNF-α和MCP-1均呈正相关。结论T2DM患者高表达的CTRP1可能通过促炎反应上调炎症因子TNF-α和炎症趋化因子MCP-1的表达,诱导DPN的发生。Objective To investigate the role of CTRP1 pro-inflammatory response in the development of diabetic peripheral neuropathy(DPN).Methods From August 2017 to November 2020,58 T2DM patients(T2DM group),58 DPN patients(DPN group),and 60 healthy subjects(HC group)were enrolled in the Second Affiliated Hospital of Zhengzhou University.The levels of serum adipose factor CTRP1,inflammatory related factors TNF-α,IL-1β,IL-6 and inflammatory chemokine MCP-1 were detected by enzyme linked immunosorbent assay(ELISA).Results The fasting blood glucose and glycosylated hemoglobin in DNP group were significantly higher than those in T2DM group,and the levels of CTRP1,TNF-αand MCP-1 in DNP group were also significantly higher than those in T2DM group.Pearson correlation analysis and Logistics regression analysis showed that CTRP1,TNF-αand MCP-1 were closely related to the occurrence of DNP,and were independent influencing factors of DPN.CTRP1 correlation analysis showed that serum CTRP1 level was positively correlated with TNF-αand MCP-1.Conclusion The high expression of CTRP1 in T2DM patients may induce the occurrence of DPN by up-regulating the expression of inflammatory cytokines TNF-αand inflammatory chemokine MCP-1.

关 键 词：2型糖尿病 周围神经病变 补体C1q肿瘤坏死因子相关蛋白1 炎症因子 

分 类 号：R587.2[医药卫生—内分泌]