2020年许昌市健康人群白喉抗体水平调查  

Diphtheria antibody levels and sero-prevalence among healthy people of Xuchang city in 2020

作　　者：耿少良[1] 赵鸣[1] 郭沙沙[1] 张丹[1] 夏晖[1] 万思嘉 从克[1] 郑惠平[1] Geng Shaoliang;Zhao Ming;Guo Shasha;Zhang Dan;Xia Hui;Wan Sijia;Cong Ke;Zheng Huiping(Xuchang Municipal Center for Disease Control and Prevention,Xuchang 461000,Henan,China)

机构地区：[1]许昌市疾病预防控制中心,河南许昌461000

出　　处：《中国疫苗和免疫》2021年第5期537-539,共3页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解2020年许昌市健康人群白喉抗体水平。方法采用分层随机抽样方法选取0-79岁健康人群,采用酶联免疫吸附试验检测血清白喉IgG抗体,分析抗体阳性率和几何平均浓度(Geometric mean concentration,GMC)。结果2020年许昌市健康人群白喉IgG抗体总阳性率为75.80%(761/1004),GMC为0.03IU/mL;各年龄组白喉IgG抗体阳性率在39.39%(45-59岁)-98.44%(1-2岁)之间(χ^(2)=267.73,P<0.001),GMC在0.003IU/mL(45-59岁)-0.13 IU/mL(<1岁和1-2岁)之间(F=73.25,P<0.001);在0-14岁儿童中,有、无/不详白喉免疫史者抗体阳性率分别为96.53%(473/490)、75.00%(12/16)(χ^(2)=18.06,P<0.001),GMC分别为0.10、0.04IU/mL(t=9.98,P=0.06)。结论许昌市健康人群白喉抗体水平和阳性率随着年龄增长呈下降趋势;建议开展青少年或成人白喉加强免疫。Objective To assess diphtheria antibody levels and sero-prevalence among healthy people of Xuchang city in 2020.Methods We used a stratified random sampling method to recruit 0-79-year-old healthy people and obtained serum samples to test for diphtheria IgG antibody using an enzyme-linked immunosorbent assay to determine sero-positivity rates and geometric mean concentrations(GMCs)of anti-diphtheria antibody.Results The overall sero-positivity rate of diphtheria antibody among healthy people of Xuchang in 2020 was 75.80%(761/1004)and the GMC was 0.03IU/mL.Positivity rates by age group ranged from 39.39%(among 45-59-year-olds)to 98.44%(among 1-2-year-olds)(χ^(2)=267.73,P<0.001)with GMCs ranging from 0.003IU/mL(45-59-year-olds)to 0.13 IU/mL(<1-and 1-2-year-olds)(F=73.25,P<0.001).Among 0-14-year-olds,positivity rates for children who received diphtheria containing vaccine and who did not received or whose vaccination histories were unknown were 96.53%(473/490)and 75.00%(12/16)(χ^(2)=18.06,P<0.001),with GMCs being 0.10 and 0.04IU/mL(t=9.98,P=0.06).Conclusions Antibody levels against diphtheria and seropositivity decreased with increasing age in healthy people in Xuchang.We recommend booster immunization for adolescents and adults.

关 键 词：白喉 IGG抗体 阳性率 几何平均浓度 健康人群 

分 类 号：R186[医药卫生—流行病学]