氯吡格雷预防冠心病介入治疗心血管的临床效果研究  

Study on the Clinical Effect of Clopidogrel in the Prevention of Cardiovascular Disease after Interventional Therapy

作　　者：王彬[1] WANG Bin(Department of Cardiology,Jixi People's Hospital,Jixi,Heilongjiang Province,158100 China)

机构地区：[1]鸡西市人民医院心内科,黑龙江鸡西158100

出　　处：《中外医疗》2021年第25期105-108,共4页China & Foreign Medical Treatment

摘　　要：目的针对冠心病介入治疗患者采用氯吡格雷对预防心血管不良事件的应用效果展开研究。方法该次研究患者均为接受冠心病介入治疗的患者,共计随机选择56例作为研究对象,研究时间为2018年7月—2019年7月,针对患者采取电脑随机分组的方式分为两组,一组接受低分子肝素治疗,为参比组,共计28例,另一组接受氯吡格雷治疗,为研究组,同样共计28例,针对两组患者治疗效果展开对比研究。结果研究组凝血功能相关指标与参比组,差异无统计学意义(t=0.880、0.192、0.029、0.312,P>0.05);研究组不同时间节点血栓素B2的水平均较参比组明显更低,差异有统计学意义(t=3.243、3.857、9.276,P<0.05);研究组心血管不良事件发生率7.14%明显较参比组46.43%更低,差异有统计学意义(χ^(2)=11.018,P<0.05);研究组临床治疗总有满意度96.43%明显较参比组64.29%更高,差异有统计学意义(χ^(2)=9.164,P<0.05);研究组生活质量各项评分均高于参比组,差异有统计学意义(t=13.492、11.059、12.195、14.340,P<0.05)。结论通过运用氯吡格雷治疗,能够对冠心病介入治疗后心血管不良事件的发生起到积极的预防作用,值得进一步推广。Objective To study the application effect of clopidogrel in the prevention of cardiovascular adverse events in patients with coronary heart disease undergoing interventional therapy.Methods All the patients in this study were patients receiving interventional therapy for coronary heart disease,a total of 56 patients were randomly selected as the study objects,and the study period was from July 2018 to July 2019.The patients were randomly divided into two groups by computer.The first group received low-molecular-weight heparin treatment,and the second group was the reference group,a total of 28 patients,the other group received clopidogrel treatment as the study group,also a total of 28 patients,and conducted a comparative study on the treatment effect of the two groups.Results There was no significant difference in coagulation function related indexes between the study group and the reference group(t=0.880,0.192,0.029,0.312,P>0.05);the changes in thromboxane B2 levels at different time nodes in the study group were significantly lower than those in the reference group,and the difference was statistically significant(t=3.243,3.857,9.276,P<0.05);the incidence of cardiovascular adverse events in the study group was 7.14%significantly lower than that in the reference group 46.43%,and the difference was statistically significant(χ^(2)=11.018,P<0.05);the clinical treatment satisfaction of the study group was 96.43%significantly higher than that of the reference group 64.29%,and the difference was statistically significant(χ^(2)=9.164,P<0.05);the quality of life scores in the study group were higher than those in the reference group,and the difference was statistically significant(t=13.492,11.059,12.195,14.340,P<0.05).Conclusion Through the use of clopidogrel therapy,it can play a positive role in preventing the occurrence of cardiovascular adverse events after interventional treatment of coronary heart disease,and it is worthy of further promotion.

关 键 词：氯吡格雷 冠心病 介入治疗 心血管不良事件 低分子肝素 临床效果 

分 类 号：R541.4[医药卫生—心血管疾病]