营养代谢对按蚊传播疟原虫能力的影响  

Influence of nutritional metabolism of Anopheles on its transmission capability of malaria parasites

作　　者：宋秀梅 王敬文 SONG Xiu-mei;WANG Jing-wen(School of Life Sciences,Fudati University^Shanghai 200438,China;Ministry of Education Key Laboratory of Contemporary Anthropologyy School of Life Sciences,Fudan Universityf Shanghai 200438,China)

机构地区：[1]复旦大学生命科学学院,上海200438 [2]复旦大学生命科学学院教育部人类学重点实验室,上海200438

出　　处：《中国寄生虫学与寄生虫病杂志》2021年第5期617-620,共4页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家自然科学基金(31822051,U1902211);美国国立卫生研究院研究计划基金(R01AI129819)

摘　　要：营养代谢为蚊虫提供多种营养物质和信号分子,保证其正常生长、发育和繁殖。同时,疟原虫也可利用按蚊的营养代谢获取养料,保证自身的发育增殖。疟原虫入侵按蚊后对按蚊营养代谢的影响,以及营养代谢在病原体入侵时如何影响蚊虫自身生殖发育、免疫反应等生理变化目前还不清楚。本文分别从糖代谢、脂代谢、氨基酸代谢等方面总结按蚊营养代谢与疟原虫之间的互作关系,为蚊媒传染病的防控提供借鉴。Nutritional metabolism of mosquitoes provides a variety of nutrients and signaling molecules to ensure their growth, development and reproduction. At the same time, malaria parasites utilize Anopheles ’ nutritional metabolism for acquisition of nutrients to ensure their own development and proliferation. Up to now, little is known regarding the impact of malaria parasite invasion on Anopheles host metabolism, and how mosquito metabolism affects itself reproduction, immune response and other physiological changes during pathogenic invasion. This review summarizes the interplay between Anopheles metabolism and malaria parasite from the aspects of metabolism of glucose, lipids and amino acids, to provide clues for development of mosquito-borne infectious diseases.

关 键 词：按蚊 疟原虫 营养代谢 

分 类 号：R384.1[医药卫生—医学寄生虫学]