SF-36和EQ-5D-5L量表在晚期血吸虫病患者生命质量评价中的比较研究  

Comparative study of SF-36 and EQ-5D-5L in evaluating quality of life for patients with advanced schistosomiasis

作　　者：刘蓉 张剑锋 严晓岚 闻礼永 LIU Rong;ZHANG Jian-feng;YAN Xiao-lan;WEN Li-yong(Hangzhou Medical University,Zhejiang Provincial Center for Schistosomiasis Control,Hangzhou 310013,China)

机构地区：[1]杭州医学院,浙江省血吸虫病防治中心,杭州310013

出　　处：《中国寄生虫学与寄生虫病杂志》2021年第5期639-646,共8页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家社会科学基金重大项目(16ZDA237)。

摘　　要：目的比较健康状况调查表(SF-36)和五水平欧洲五维度健康量表(EQ-5D-5L)用于晚期血吸虫病患者生命质量评价的效果。方法选择2020年就诊于嘉兴市某两家医院的晚期血吸虫病患者为调查对象,收集患者一般情况相关信息,包括姓名、性别、年龄、晚期血吸虫病临床分型等。分别采用SF-36和EQ-5D-5L量表进行问卷调查,比较两种量表评价晚期血吸虫病患者生命质量的信度、效度以及对于不同健康程度晚期血吸虫病患者的区分程度,并对两种量表评价得分进行相关性分析,对影响晚期血吸虫病患者生命质量的影响因素进行分析。(36.80%),女性79例(63.20%);巨脾型54例(43.20%),腹水型71例(56.80%)。SF-36量表内部一致性信度Cronbach’sα系数为0.780,主成分分析法提取2个因子,累计贡献率为70.427%;EQ-5D-5L量表内部一致性信度Cronbach’sα系数为0.850,主成分分析法提取2个因子,累计贡献率为85.884%。SF-36量表各领域中,精神健康平均得分最高(66.82±7.90),生理职能和情感职能得分最低(均为0分);生理健康总测量(PCS)平均得分(33.85±8.92),心理健康总测量(MCS)平均得分(39.76±4.93);MCS得分较高的患者数为119例,多于PCS的81例。EQ-5D-5L量表中效用指数(UI)得分平均值为(0.801±0.214);"疼痛或不舒服"维度存在"中度困难、严重困难及极度困难"患者所占比例最高(占24.80%),"焦虑或抑郁"维度最低(占5.60%)。视觉模拟标尺(EQ-VAS)评分平均值为(66.64±7.85)。年龄对患者PCS、 MCS、 EQ-VAS评分影响均较大(P <0.01),不同性别、临床分型得分之间差异无统计学意义(P> 0.05)。PCS、 MCS得分较高者UI得分、 EQ-VAS评分均高于PCS、 MCS得分较低者(P <0.01);在EQ-5D-5L中随着各维度严重程度的增加,患者PCS、 MCS得分降低(P <0.01)。PCS与UI得分、 EQ-VAS评分具有相关性(r=0.716、 0.689, P <0.01), MCS与UI得分、 EQ-VAS评分具有相关性(r=0.622、 0.544, P <0.01)。结论 SFObjective To compare the effects of the 36-item short form health survey(SF-36) and the fivelevel EuroQol five-dimensional questionnaire(EQ-5 D-5 L) on the quality of life of patients with advanced schistosomiasis. Methods A total of 125 patients with advanced schistosomiasis were selected from two hospitals in Jiaxing City in 2020, and the general information of the patients was collected, including name, sex, age, and clinical classification of advanced schistosomiasis. The SF-36 and EQ-5 D-5 L scales were used in questionnaire;investigate the quality of life of patients with advanced schistosomiasis, the reliability and validity of the two scales in evaluating the quality of life of patients with advanced schistosomiasis, and the degree of differentiation in patients with different health levels were compared. The correlation between the scores of the two scales and the factors influencing patient scores were also analyzed. Results The 125 patients with advanced schistosomiasis ranged in age from 47 to 93 years, with an average age of(75.04 ± 7.53) years. There were 46 males(36.80%) and 79 females(63.20%). There were 54 cases(43.20%) of splenomegaly type and 71 cases(56.80%) of ascitic type. The Cronbach ’s α coefficient of internal coherence in SF-36 was 0.780 and two factors were extracted by principal component analysis, with a cumulative contribution rate of 70.427%. The Cronbach ’s α coefficient of EQ-5 D-5 L was0.850 and two factors were extracted by principal component analysis, with a cumulative contribution rate of85.884%. Among the dimensions of SF-36, the highest average score was on mental health(66.82 ± 7.90), and the lowest scores were on role physical(0) and role emotional(0);the average score of physical component summary(PCS) was(33.85 ± 8.92) and mental health measurement(MCS) was(39.76 ± 4.93), and number of patients with higher MCS score were higher than those with PCS. The average EQ-5 D-5 L utility index(UI) score was(0.801 ±0.214). The patients with the dimension of "pain or d

关 键 词：SF-36量表 EQ-5D-5L量表 晚期血吸虫病 生命质量 信度 效度 

分 类 号：R532.21[医药卫生—内科学]