人体主动脉瓣膜钙化组织的力学性质  

Mechanical Properties of Calcification from Human Aortic Valve

作　　者：杨贤达[1] 冯文韬[1] 刘琨[2] 张海波[2] 姚杰[1] 冯成龙 王丽珍[1] 樊瑜波[1] YANG Xianda;FENG Wentao;LIU Kun;ZHANG Haibo;YAO Jie;FENG Chenglong;WANG Lizhen;FAN Yubo(Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education,Beijing Advanced innovation Centre for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing,100083,China;Department of Cardiac Surgery^Beijing Anzhen Hospital,Capital Medical University,Beijing、100029,China)

机构地区：[1]北京航空航天大学生物力学与力生物学教育部重点实验室,北京市生物医学工程高精尖创新中心,生物与医学工程学院,北京100083 [2]首都医科大学附属安贞医院心外科,北京100029

出　　处：《医用生物力学》2021年第5期747-750,共4页Journal of Medical Biomechanics

基　　金：国家重点研发计划(2017YFB0702500);北京自然科学基金项目(7194287);科技部创新人才推进计划重点领域创新团队(11421201);国家重大科研仪器设备研制专项(11827803)。

摘　　要：目的采用纳米压痕测试方法,测量人体主动脉瓣取出物的钙化组织的材料力学性能。方法采集5名主动脉瓣狭窄患者的瓣叶取出物,选取钙化瓣叶进行纳米压痕测试,获得钙化组织弹性模量、硬度等材料力学参数。结果瓣叶钙化组织的弹性模量为(15.69±3.89)GPa,硬度为(0.59±0.15)GPa。结论通过纳米压痕测试方法得到瓣叶钙化组织的弹性模量和硬度,为瓣膜的生物力学研究提供实验数据参考。Objective To measure mechanical properties of calcified tissues from human aortic valve by nanoindentation test.Methods Leaflets from 5 patients with aortic stenosis were collected.Elastic modulus and hardness of the calcified leaflets were obtained by nanoindentationtest.Results The elastic modulus and hardness of the calcified leaflets were(15.69±3.89)GPa and(0.59±0.15)GPa,respectively.Conclusions The elastic modulus and hardness of the calcified valve tissues can be obtained by nanoindentationtest,which provides experimental data for biomechanical research of the valve.

关 键 词：主动脉瓣 瓣叶 钙化组织 纳米压痕 弹性模量 

分 类 号：R318.01[医药卫生—生物医学工程]