Cervicovaginal microbiome dynamics after taking oral probiotics  

作　　者：Chen Chen Lilan Hao Zhe Zhang Liu Tian Xiaowei Zhang Jie Zhu Zhuye Jie Xin Tong Liang Xiao Tao Zhang Xin Jin Xun Xu Huanming Yang Jian Wang Karsten Kristiansen Huijue Jia 

机构地区：[1]BGI-Shenzhen,Shenzhen 518083,China [2]Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research,BGI-Shenzhen,Shenzhen 518083,China [3]Laboratory of Genomics and Molecular Biomedicine,Department of Biology,Universitetsparken 13,University of Copenhagen,Denmark [4]Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome,BGI-Shenzhen [5]BGI-Qingdao,BGI-Shenzhen,Qingdao 266555,China [6]James D.Watson Institute of Genome Sciences,Hangzhou 310058,China

出　　处：《Journal of Genetics and Genomics》2021年第8期716-726,共11页遗传学报（英文版）

摘　　要：The vaginal microbiota is less complex than the gut microbiota,and the colonization of Lactobacillus in the female vagina is considered to be critical for reproductive health.Oral probiotics have been suggested as promising means to modulate vaginal homeostasis in the general population.In this study,60 Chinese women were followed for over a year before,during,and after treatment with the probiotics Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14.Shotgun metagenomic data of 1334 samples from multiple body sites did not support a colonization route of the probiotics from the oral cavity to the intestinal tract and then to the vagina.Our analyses enable the classification of the cervicovaginal microbiome into a stable state and a state of dysbiosis.The microbiome in the stable group steadily maintained a relatively high abundance of Lactobacilli over one year,which was not affected by probiotic intake,whereas in the dysbiosis group,the microbiota was more diverse and changed markedly over time.Data from a subset of the dysbiosis group suggests this subgroup possibly benefited from supplementation with the probiotics,indicating that probiotics supplementation can be prescribed for women in a subclinical microbiome setting of dysbiosis,providing opportunities for targeted and personalized microbiome reconstitution.

关 键 词：Oral probiotics Cervicovaginal microbiome Shotgun metagenomic data 

分 类 号：R37[医药卫生—病原生物学]