Genomic analyses reveal distinct genetic architectures and selective pressures in Chinese donkeys  

作　　者：Jiafei Shen Jie Yu Xuelei Da Mei Li Gang Wang Ningbo Chen Hong Chen Chuzhao Lei Ruihua Dang 

机构地区：[1]Key Laboratory of Animal Genetics,Breeding and Reproduction of Shaanxi Province,College of Animal Science and Technology,Northwest A&F University,Yangting,Shaanxi 712100,China

出　　处：《Journal of Genetics and Genomics》2021年第8期737-745,共9页遗传学报（英文版）

基　　金：supported by the Key Research&Development Plan of Shaanxi Province of China(2020NY-002);Dong-E-E-Jiao Co.Ltd(20191001);the National Natural Science Foundation of China(81770514)。

摘　　要：Donkey(Equus asinus)is an important livestock animal in China because of its draft and medicinal value.After a long period of natural and artificial selection,the variety and phenotype of donkeys have become abundant.We clarified the genetic and demographic characteristics of Chinese domestic donkeys and the selection pressures by analyzing 78 whole genomes from 12 breeds.According to population structure,most Chinese domestic donkeys showed a dominant ancestral type.However,the Chinese donkeys still represented a significant geographical distribution trend.In the selective sweep,gene annotation,functional enrichment,and differential expression analyses between large and small donkey groups,we identified selective signals,including NCAPG and LCORL,which are related to rapid growth and large body size.Our findings elucidate the evolutionary history and formation of different donkey breeds and provide theoretical insights into the genetic mechanism underlying breed characteristics and molecular breeding programs of donkey clades.

关 键 词：DONKEY Whole-genome resequencing NCAPG LCORL 

分 类 号：S822.2[农业科学—畜牧学]