比较可调钠曲线透析联合序贯透析治疗终末期肾病伴顽固性高血压的临床效果  

Comparison of the Clinical Effects of Adjustable Sodium Curve Dialysis Combined with Sequential Dialysis in the Treatment of End-stage Renal Disease with Refractory Hypertension

作　　者：李晓霞 曾继仁 LI Xiaoxia;ZENG Jiren(Puning Yangke Shenanalysis Hemodialysis Center,Puning,Guangdong Province,515300 China;Huilai Yangke Renal Analysis Hemodialysis Center,Huilai,Guangdong Province,515200 China)

机构地区：[1]普宁养可肾析血液透析中心,广东普宁515300 [2]惠来养可肾析血液透析中心,广东惠来515200

出　　处：《系统医学》2021年第17期77-79,共3页Systems Medicine

摘　　要：目的研究可调钠曲线透析联合序贯透析治疗终末期肾病伴顽固性高血压的效果。方法选取2019年7月—2020年7月普宁、惠来养可肾析血液透析中心的74例患者进行随机分组,各37例,其中钠曲线温度曲线联合序贯透析的为联合组,采用常规透析治疗的为常规组,比较两组患者相关指标情况。结果治疗后,联合组hs-CRP水平(12.36±3.63)mg/L明显低于常规组,差异有统计学意义(t=3.708,P<0.05),钠离子水平(139.74±2.57)mmol/L与常规组比较,差异无统计学意义(t=0.117,P>0.05);治疗前两组收缩压和舒张压比较,差异无统计学意义(P>0.05),治疗后均下降,联合组收缩压(140.36±11.20)mmHg、舒张压为(61.35±5.13)mmHg优于常规组,差异有统计学意义(t=5.544、6.506,P<0.05);联合组肾素-血管紧张素Ⅱ(102.36±9.63)mmHg低于常规组,差异有统计学意义(t=4.082,P<0.05),但两组尿素氮、肌酐对比差异无统计学意义(t=1.543、1.490,P>0.05)。结论在对终末期肾病伴顽固性高血压患者进行治疗时,采用可调钠曲线透析治疗方案获得的治疗效果要相对优于常规透析治疗方案,其对患者体内炎性因子、血压水平的改善较明显,临床适用度更高。Objective To study the effect of adjustable sodium curve dialysis combined with sequential dialysis in the treatment of end-stage renal disease with refractory hypertension.Methods A total of 74 patients from Pening and Huilai Yangke Nephrodialysis centers from July 2019 to July 2020 were selected and randomly divided into 37 patients in each group.The sodium curve temperature curve combined with sequential dialysis was the combined group,and the routine dialysis was the conventional group.The related indicators of patients in the two groups were compared.Results After treatment,the hs-CRP level of combined group was significantly lower than that of conventional group,the difference was statistically significant(t=3.708,P<0.05),and the sodium ion level of(139.74±2.57)mmol/L compared the conventional group,the difference was not statistically significant(t=0.117,P>0.05).Systolic blood pressure and diastolic blood pressure in the combined group(140.36±11.20)mmHg and(61.35±5.13)mmHg were higher than those in the conventional group,the difference was statistically significant(t=5.544,6.506,P<0.05).Renin-angiotensin II(102.36±9.63)mmHg in the combined group was lower than that in the conventional group,the difference was statistically significant(t=4.082,P<0.05),but there were no significant differences in urea nitrogen and creatinine between the two groups,the difference was not statistically significant(t=1.543,1.490,P>0.05).Conclusion In the treatment of patients with end-stage renal disease accompanied by intractable hypertension,the treatment effect of using adjustable sodium curve dialysis is relatively better than that of conventional dialysis,and it can significantly improve the inflammatory factors and blood pressure levels in patients,with higher clinical applicability.

关 键 词：可调钠曲线透析 序贯透析治疗 终末期肾病 顽固性高血压 

分 类 号：R544.1[医药卫生—心血管疾病] R459.5[医药卫生—内科学]