痛风性关节炎并胰岛素抵抗及其危险因素分析  

Analysis of Insulin Resistance and Risk Factors in Primary Gouty Arthritis:AClinical Study

作　　者：李艳华[1] 蔡小燕[2] LI Yan-hua;CAI Xiao-yan(Guangzhou Medical University,Department of Nephrology&Rheumatology,Nanhai district people's hospital,Foshan,528000;Department of Rheumatology,Guangzhou First People's Hospital,Guangzhou)

机构地区：[1]广州医科大学广东省佛山市南海区人民医院肾脏风湿免疫科,528000 [2]广东省广州市第一人民医院风湿免疫科

出　　处：《岭南急诊医学杂志》2021年第5期499-501,506,共4页Lingnan Journal of Emergency Medicine

基　　金：广东省佛山市卫生和计生局医学科研课题(20190233)。

摘　　要：目的:提高临床医师对痛风合并胰岛素抵抗的认识。方法:回顾性分析2020年01月01日至2020年12月31日在佛山市南海区人民医院肾脏风湿免疫科住院的原发性痛风急性发作患者的临床资料,根据胰岛素水平分为胰岛素抵抗组、非胰岛素抵抗组。结果:2组间男性比例、年龄、病程、VAS评分等比较差异无统计学意义。胰岛素抵抗组比非胰岛素抵抗组体质指数、甘油三酯水平更高,ApoA1/ApoB比值更低,差异具有统计学意义(P<0.05)。Logistic回归分析提示痛风患者体质指数与胰岛素抵抗呈正相关,ApoA1/ApoB比值呈负相关。结论:高体质指数、ApoA1/ApoB比值下降的痛风患者应积极防治胰岛素抵抗的发生。Objective:To improve clinicians. understanding of gout associated with insulin resistance. Methods:62 cases of primary gouty arthritis with acute attack were collected,summarized the characteristics and concluded the therapeutic process. Results:Patients were divided into insulin resistance(IR)group and non-insulin resistance(non-IR)group according to their insulin level. There were no statistically significant differences in male proportion,age,course of disease,VAS score,etc. between the two groups.The body mass index(BMI)and the triacylglycerol of the IR group was higher than non-IR group,while the ratio of ApoA1/ApoB was lower,and the statistical difference was significant. Logistic regression indicated that BMI was positively correlated with insulin resistance in patients with gout,while the ratio of ApoA1/ApoB was negative. Conclusion:Patients with high body mass index,and low ApoA1/ApoB ratio of gout should actively prevent the occurrence of insulin resistance.

关 键 词：痛风 胰岛素抵抗 危险因素 

分 类 号：R589.7[医药卫生—内分泌]