H亚型血管在股骨头坏死中的作用机制研究进展  

Progress of developmental mechanism of subtype H vessels in osteonecrosis of the femoral head

作　　者：马金辉[1] 任岩松 王佰亮[1] 孙伟[1] 岳德波[1] 王卫国[1] MA Jinhui;REN Yansong;WANG Bailiang;SUN Wei;YUE Debo;WANG Weiguo(Department of Orthopedic Surgery,China-Japan Friendship Hospital,Beijing,100029,P.R.China;Peking University China-Japan Friendship School of Clinical Medicine,Beijing,100029,P.R.China)

机构地区：[1]中日友好医院骨科,北京100029 [2]北京大学中日友好临床医学院,北京100029

出　　处：《中国修复重建外科杂志》2021年第11期1486-1491,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：北京市自然科学基金青年项目(7204301);中央高校基本科研业务费专项资金(3332021088)。

摘　　要：目的综述H亚型血管在股骨头坏死(osteonecrosis of the femoral head,ONFH)发生发展中的作用机制研究进展。方法广泛查阅国内外相关文献,总结H亚型血管的组织学特点、促进成骨生物学机制,探讨其在ONFH发生发展中的作用机制。结果 H亚型血管是一种新发现的骨内血管,主要分布于干骺端和骨内膜,高表达内皮黏蛋白和CD31,可分泌与骨祖细胞存活和增殖相关的生长因子,周围聚集大量Osterix阳性骨祖细胞、Ⅰ型α胶原蛋白阳性成骨细胞和Runx2阳性早期骨祖细胞,这些细胞能分泌VEGF促进血管生成,具有诱导骨形成和血管生成的能力。PDGF-BB、裂隙引导配体3、HIF-1α、Notch信号通路和VEGF等参与了H亚型血管促进成骨的生物学机制。结论 H亚型血管在骨组织修复重建过程中对血管生成和骨形成起重要调节作用,该型血管的发现揭示了血管生成和骨形成之间协同作用的生物学机制。针对调控H亚型血管的新技术可能成为治疗ONFH的新方法。Objective To review the research progress of subtype H vessels in the occurrence and development of osteonecrosis of the femoral head(ONFH). Methods The relevant domestic and foreign literature was extensively reviewed. The histological features, biological mechanism of subtype H vessels involved in promoting of osteogenesis, and the role and application of the subtype H vessels in ONFH were summarized. Results The subtype H vessel is a newly discovered bone vessel, mainly distributed in metaphysis and subperiosteum, highly expressing endomucin and CD31.The subtype H vessel has a dense arrangement of Runx2+ early osteoprogenitors, collagen type Ⅰα+ osteoblast cells, and Osterix+ osteoprogenitors that have the ability to induce osteogenesis and angiogenesis. Factors such as platelet-derived growth factor BB, slit guidance ligand 3, hypoxia inducible factor 1α, Notch signaling pathway, and vascular endothelial growth factor are involved in the mechanism of subtype H vessels in promoting osteogenesis. Conclusion Subtype H vessels play an important role in the regulation of angiogenesis and osteogenesis during bone tissue repair and reconstruction. The discovery of subtype H vessels provides new insights into the molecular and cellular mechanisms of osteogenesis and angiogenesis coupling. In the future, new techniques targeting the regulation of subtype H blood vessels may become a promising method for the treatment of ONFH.

关 键 词：H亚型血管 股骨头坏死 血管形成 骨形成 

分 类 号：R681.8[医药卫生—骨科学]