人体唾液成分与骨质疏松/骨量低下  

Human salivary components and osteoporosis/osteopenia

作　　者：朱婵 韩栩珂 姚承佼 周倩[1,2] 张强[3] 陈秋[1,2] Zhu Chan;Han Xuke;Yao Chengjiao;Zhou Qian;Zhang Qiang;Chen Qiu(Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,Sichuan Province,China;Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China;Sichuan Provincial Orthopedic Hospital,Chengdu 610041,Sichuan Province,China)

机构地区：[1]成都中医药大学附属医院,四川省成都市610072 [2]成都中医药大学,四川省成都市610075 [3]四川省骨科医院,四川省成都市610041

出　　处：《中国组织工程研究》2022年第9期1439-1444,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家重大疑难疾病中西医临床协作项目(CYW2019079),项目负责人:陈秋;国家中医药管理局项目[SATCM-2015-BZ(204)],项目负责人:陈秋;成都市重点科技应用示范项目(2019-YF09-00094-SN),项目负责人:陈秋。

摘　　要：背景:骨质疏松症是全世界面临的重要公共健康问题,危险人群的早期筛查和诊断可有效预防脆性骨折的发生。唾液作为一种非侵入性和安全的来源,有望在疾病的诊断和预后中发挥替代血液的作用。目的:回顾唾液成分分析在骨质疏松/骨量低下领域的研究,以期找到最有前途和价值的唾液诊断标志物。方法:计算机检索PubMed、EMbase、The Cochrane Library、Web of Science以及中国知网、维普数据库、万方数据库、中国生物医学文献数据库等数据库,检索截止时间至2021-06-01,同时检索其他相关灰色文献,获取所有涉及唾液成分与骨质疏松/骨量分析的相关研究,评价其方法学质量,筛选符合纳排标准的试验,并提取研究中的受试者信息、诊断方法、观察指标及试验结果等相关资料。结果与结论:共有8篇符合标准的唾液成分与骨量低下/骨质疏松的相关性研究,其中横断面研究5篇(高质量文献2篇,中等质量文献3篇),病例-对照研究3篇(高质量文献1篇,中等质量文献2篇);关注了12种唾液成分指标,分别是唾液矿物质(钙、锌、磷、铜),唾液中的典型骨转换标志物(碱性磷酸酶、骨钙素、C-末端肽交联CTX、Ⅰ型原胶原N-端前肽P1NP),唾液中的某些生物活性肽(胃饥饿素、肥胖抑制素、α-防御素)以及唾液pH值。唾液钙可能是诊断骨质疏松症最有潜力的唾液指标之一,唾液皮质醇与骨量的关系值得深入研究。BACKGROUND:Osteoporosis is a critical public health issue among the world.Early screening and diagnosis for high-risk groups can effectively prevent the occurrence of osteoporosis related fractures.As a non-invasive and safe strategy,saliva is expected to be alternative choice in the diagnosis and prognosis of diseases.OBJECTIVE:To investigate the potential salivary diagnostic markers through systematically reviewing the current studies of salivary component analysis in osteoporosis/osteopenia.METHODS:Databases,including PubMed,EMbase,The Cochrane Library,Web of Science,Chinese National Knowledge Infrastructure(CNKI),Chinese Science and Technology Periodical database(VIP),Wanfang database,and Chinese Biomedical database(CBM),were searched from inception to June 1,2021 to collect all related trials.Grey literature was also searched.All relevant studies involving salivary component and osteoporosis/bone mass analysis were obtained to evaluate its methodological quality and to screen tests that met the inclusion and exclusion criteria;methodological quality was evaluated;baseline characteristics,diagnostic methods,observation indicators,and test results were recorded.RESULTS AND CONCLUSION:A total of eight relevant trials were selected in this review.Among them,there were five cross-sectional studies(two high-quality articles and three medium-quality articles)and three case-control studies(one high-quality article and two medium-quality articles).Eight included trials focused on 12 salivary components,including salivary minerals(Calcium,Zinc,Phosphorus,Copper),typical bone turnover markers(alkaline phosphatase,osteocalcin,CTX,P1NP),bioactive peptides(Ghrelin,Obestatin,α-defensins)and salivary pH value.Salivary calcium might be the most promising salivary markers for osteoporosis;nevertheless,the relationship between salivary cortisol and bone mass deserves further study.

关 键 词：唾液 唾液钙 生化标志物 骨质疏松 骨量减少 系统综述 

分 类 号：R446[医药卫生—诊断学] R332[医药卫生—临床医学]