小儿慢性乙型肝炎聚乙二醇干扰素α-2a治疗的个案报道  

Case report of using pegylated interferon alpha-2a in the treatment of child with chronic hepatitis B

作　　者：王维[1] 唐伟平 朱娜玲 罗雅丽[1] 王利玲 刘志华[2] WANG Wei;TANG Wei Ping;ZHU Na Ling;LUO Ya Li;WANG Li Ling;LIU Zhi Hua(Bao'an District Maternal and Child Health Care Hospital,Shenzhen 518102,Guangdong Province,China;Nanfang Hospital,Guangzhou 510515,Guangdong Province,China)

机构地区：[1]深圳市宝安区妇幼保健院,广东深圳518102 [2]广州市南方医院,广东广州510515

出　　处：《中国妇幼卫生杂志》2021年第4期73-77,共5页Chinese Journal of Women and Children Health

基　　金：深圳市宝安区科技计划项目(2019JD372);深圳市基础研究专项(面上项目)(自然科学基金)(JCYJ20190809181805708);中国性病艾滋病防治协会·艾伯维妇幼关爱及预防母婴传播基金(PMTCT201905)。

摘　　要：目的报告分析聚乙二醇干扰素α-2a注射液(Peg-IFN-α-2a)治疗慢性乙型肝炎(chronic hepatitis B,CHB)(乙肝)儿童的个案。方法使用Peg-IFN-α-2a治疗一例乙肝e抗原(HBe Ag)阳性的CHB儿童。治疗和随访期间收集临床和实验室资料并进行分析。结果患儿使用Peg-IFN-α-2a治疗24周后,HBe Ag和乙肝表面抗原(HBs Ag)均转为阴性,乙肝病毒DNA(HBV DNA)由6.20 lg IU/ml降至低于检测线,丙氨酸氨基转移酶(ALT)恢复至正常水平,并且产生了乙肝表面抗体(抗-HBs),患儿在治疗中先后出现发热,粒细胞减少等不良反应。结论使用Peg-IFN-α-2a治疗CHB患儿可能是一种安全有效的抗病毒药物,可为后续确定适合CHB儿童的抗病毒治疗方案提供理论依据。Objective To report and analyze a case of using pegylated interferon alpha-2 a injection(Peg-IFN-α-2 a)in the treatment of a child with chronic hepatitis B(CHB).Methods Peg-IFN-α-2 a was used to treat a CHB child with positive hepatitis B e antigen(HBe Ag).Clinical and laboratory data were collected and analysed during treatment and follow-up.Results After 24 weeks of treatment with Peg-IFN-α-2 a,both HBe Ag and hepatitis B surface antigen(HBs Ag)seroconversion preceded,and hepatitis B virus(HBV)DNA dropped from 6.20 lg IU/ml to the line that undetected.Aminotransferase(ALT)decreased to normal level,and HBV surface antibodies(anti-HBs)were present.The child experienced fever and neutropenia symptoms during treatment.Conclusion Using Peg-IFN-α-2 a as antiviral drug might provide a safe and effective treatment option for children with CHB.It would provide theoretical evidence for subsequent development of antiviral treatment protocol for them.

关 键 词：聚乙二醇干扰素Α-2A 儿童 慢性乙型肝炎 

分 类 号：R725.1[医药卫生—儿科]