2~8℃低温干预结合复方茶多酚含漱液在鼻咽癌患者放射性口腔黏膜炎预防中的应用及OM发生的危险因素  

The application of 2~8℃low temperature intervention combined with compound tea polyphenol gargle in the prevention of radiation-induced oral mucositis in patients with nasopharyngeal carcinoma and the risk factors of OM

作　　者：秦艳梅[1] 付喜秀[1] 陈森[1] 盘玉飞 陶娜 赵小梅 杨芳 Qin Yanmei;Fu Xixiu;Chen Sen;Pan Yufei;Tao Na;Zhao Xiaomei;Yang Fang(Nanxishan Hospital of Guangxi Zhuang Autonomous Region,Guilin 541002,China)

机构地区：[1]广西壮族自治区南溪山医院,桂林541002

出　　处：《国际护理学杂志》2021年第21期3921-3926,共6页international journal of nursing

基　　金：广西卫生健康委自筹经费科研课题(Z20180557)。

摘　　要：目的探讨2~8℃低温干预结合复方茶多酚含漱液在鼻咽癌患者放射性口腔黏膜炎预防中的应用及OM发生的危险因素。方法选取2019年4月至2020年3月该院确诊的鼻咽癌患者120例, 将所有患者按照随机原则分为观察组和对照组, 每组60例。所有患者均采取适形调强放射治疗(IMRT), 治疗同时, 两组患者均采取常规基础护理, 观察组采取2~8℃低温(生理盐水100 ml+地塞米松5 mg+利多卡因10 mg等混合药液)干预联合复方茶多酚含漱液护理, 对照组采取碳酸氢钠液含漱。比较两组患者发生放射性口腔黏膜炎、发生放射性口腔黏膜炎的时间、生活质量之间的差异, 分析重度放射性口腔黏膜炎患者之间的差异, 采用Logistics对造成患者重度口腔黏膜损伤的因素进行分析。结果两组患者发生放射性口腔黏膜炎之间的差异有统计学意义(P<0.05);两组患者发生放射性口腔黏膜炎时间的差异有统计学意义(P<0.05);经过护理后, 患者的日常活动、家庭生活、情绪、活动能力等情况评分均显著上升, 且观察组患者的日常活动、家庭生活、情绪、活动能力等情况评分显著高于对照组, 差异有统计学意义(P<0.05);通过对重度放射性口腔黏膜炎患者的一般资料进行比较, 两组患者的职业环境、吸烟、饮酒、口腔pH以及TNM分期差异有统计学意义(P<0.05);通过对重症口腔粘膜炎患者的多因素分析, 职业环境(室外)、吸烟、饮酒、口腔pH(≤7)、TNM分期(Ⅲ)均为造成患者重度放射性口腔黏膜炎的独立危险因素。结论 2~8℃低温(生理盐水100 ml+地塞米松5 mg+利多卡因10 mg等混合药液)干预联合复方茶多酚含漱液对于鼻咽癌患者放射性口腔黏膜炎预防具有显著的预防性作用, 同时建议职业环境(室外)、吸烟、饮酒、口腔PH(≤7)、TNM分期(Ⅲ)患者作为重点关注对象。Objective To explore the application of 2~8℃low temperature intervention combined with compound tea polyphenol gargle in the prevention of radiation-induced oral mucositis in patients with nasopharyngeal carcinoma and the risk factors of OM.Methods A total of 120 patients with nasopharyngeal carcinoma diagnosed in this hospital from April 2019 to March 2020 were selected,and all patients were randomly divided into observation group and control group,with 60 cases in each group.All patients were treated with Intensity-modulated radiation therapy(IMRT).At the same time,both groups were treated with routine nursing.The observation group was treated with 2〜8℃(Normal saline 100 ml+dexamethasone 5 mg+lidocaine 10 mg)hypothermia intervention combined with compound tea polyphenol gargle nursing,while the control group was gargled with sodium bicarbonate.The differences between the occurrence of radioactive oral mucositis,the occurrence of radioactive oral mucositis and the quality of life between the two groups were compared,the differences between the patients with severe radioactive oral mucositis were analyzed,and the factors causing severe oral mucositis were analyzed by Logistics.Results The difference between the two groups of patients with radioactive oral mucositis was statistically significant(P<0.05).The difference in the occurrence time of radioactive oral mucositis between the two groups was statistically significant(P<0.05).After nursing,scores of daily activities,family life,mood and activity ability of patients were significantly increased,and scores of daily activities,family life,mood and activity ability of patients in the observation group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).By comparing the general data of patients with severe radioactive oral mucositis,the differences of occupational environment,smoking,drinking,oral pH and TNM stage Between the two groups were statistically significant(P<0.05).Occupational environment(o

关 键 词：2~8℃低温干预 复方茶多酚含漱液 鼻咽癌 放射性口腔黏膜炎 

分 类 号：R473.73[医药卫生—护理学]