不同抗精神病药物治疗对妊娠期精神分裂患者新生儿生长发育的影响  

Effects of different antipsychotic drugs on the growth and development of newborns with schizophrenia during pregnancy

作　　者：孙玉涛[1] 卢秀春 刘彦彬 SUN Yu-tao;LU Xiu-chun;LIU Yan-bin(Department of Psychologyt,Tangshan Fifth Hospital,Tangshan 063000,China)

机构地区：[1]唐山市第五医院心理科,河北唐山063000 [2]唐山市第五医院重症精神科,河北唐山063000

出　　处：《武警后勤学院学报（医学版）》2021年第10期67-68,71,共3页Journal of Logistics University of PAP（Medical Sciences）

基　　金：河北省2021年度医学科学研究课题计划(No.20211102)。

摘　　要：【目的】探究不同抗精神病药物治疗对妊娠期精神分裂患者新生儿生长发育的影响。【方法】回顾性分析本院收治的128例妊娠期精神分裂症患者的病历资料,根据采用不同药物治疗将其分为观察组(n=64)、对照组(n=64),观察组采用氯氮平治疗,对照组采用其他非定型抗精神病药治疗,比较两组儿童躯体发育情况、智能发育情况及智能发育延迟比例。【结果】两组新生儿于出生后2、6、12个月身高、体重及1 min、5 min Apgar评分比较无差异(P>0.05);两组新生儿2、6、12个月适应行为量表评分、认知量表评分比较无差异(P>0.05),观察组新生儿2、6个月社交情感量表评分、语言量表评分、运动量表评分均低于对照组(P<0.05),12个月两组各项评分比较无差异(P>0.05);两组新生儿2、6、12个月认知、社交情感、语言、运动发育延迟比例比较无差异(P>0.05),观察组新生儿2、6个月适应行为发育延迟比例明显高于对照组(P<0.05),于12个月两组比例比较无差异(P>0.05)。【结论】妊娠期精神分裂患者采用氯氮平及其他非典型抗精神病药物治疗对新生儿躯体发育不良影响差异较小,但发育情况受氯氮平影响较为显著,部分影响多伴随至出生后6个月甚至12个月。【Objective】To explore the effects of different antipsychotic drugs on the growth and development of newborns with schizophrenia during pregnancy.【Methods】The medical records of 128 patients with schizophrenia during pregnancy collected in our hospital were analyzed retrospectively.According to different drug treatments,they were divided into observation group(n=64)and control group(n=64).The observation group was treated with clozapine and the control group was treated with other amorphous antipsychotics.The physical development,intellectual development and the proportion of intellectual development delay of children in the two groups were compared.【Results】There was no difference in height,weight and Apgar score at 1 min and 5 min between the two groups at 2,6 and 12 months after birth(P>0.05);There was no difference between the two groups in the scores of adaptive behavior scale and cognitive scale at 2,6 and 12 months(P>0.05).The scores of social emotion scale,language scale and exercise scale at 2 and 6 months in the observation group were lower than those in the control group(P<0.05).There was no difference between the two groups at 12 months(P>0.05);There was no difference between the two groups in the proportion of cognitive,social emotion,language and motor development delay at 2,6 and 12 months(P>0.05).The proportion of adaptive behavior development delay at 2 and 6 months in the observation group was significantly higher than that in the control group(P<0.05),and there was no difference between the two groups at 12 months(P>0.05).【Conclusion】The effect of clozapine and other atypical antipsychotics on neonatal physical dysplasia in patients with schizophrenia during pregnancy is less,but the development is significantly affected by clozapine,and some effects are mostly accompanied to 6 or even 12 months after birth.

关 键 词：氯氮平 抗精神病药 妊娠期 精神分裂 新生儿 

分 类 号：R714.143[医药卫生—妇产科学]