乙型肝炎诊治中血清中免疫球蛋白检验的诊断价值分析  

Analysis of the Diagnostic Value of Serum Immunoglobulin Test in Diagnosis and Treatment of Hepatitis B

作　　者：王娜[1] 李育梅[2] WANG Na;LI Yumei(Department of Laboratory Medicine,Donghai County People's Hospital,Lianyungang,Jiangsu Province,222300 China;Department of Infectious Diseases,Nantong Third People's Hospital,Nantong,Jiangsu Province,226000 China)

机构地区：[1]东海县人民医院检验科,江苏连云港222300 [2]南通市第三人民医院感染科,江苏南通226000

出　　处：《中外医疗》2021年第27期21-24,共4页China & Foreign Medical Treatment

基　　金：江苏省卫生计生委专项课题卫生标准课题(W201708)。

摘　　要：目的探讨临床在诊治乙肝患者时检验免疫球蛋白水平的价值。方法随机选取2019年1月—2021年2月该院就诊乙肝患者80例为研究组(按病情程度分轻症组38例与重症组42例),以及同期在院体检80名健康者为常规组,均予以血清免疫球蛋白检验,统计3组检验结果。结果研究组治疗后IgA(2.51±0.60)g/L、IgG(14.18±2.45)g/L、IgM(2.62±0.43)g/L、TBIL(159.42±20.17)μmol/L均高于常规组,PTA(38.74±6.87)%低于常规组,差异有统计学意义(t=11.235、12.043、9.088、56.794、28.332,P<0.05);治疗前,重症组的IgA、IgG、IgM、TBIL等指标分别为(4.21±0.98)g/L、(20.17±1.84)g/L、(3.11±0.92)g/L、(350.20±70.15)μmol/L,均高于轻症组,PTA(26.10±4.52)%低于轻症组,差异有统计学意义(t=5.844、9.989、2.996、12.783、15.955,P<0.05);治疗后,重症组的IgA、IgG、IgM、TBIL等指标分别为(3.75±0.71)g/L、(17.02±1.38)g/L、(2.75±0.70)g/L、(328.17±65.28)μmol/L,均高于轻症组,PTA(30.16±5.46)%低于轻症组,差异有统计学意义(t=10.351、7.950、3.982、11.911、12.883,P<0.05)。结论通过检测乙肝患者血清免疫球蛋白水平,可有效诊断疾病的同时,还能对患者病情进行评估,适宜临床深入研究与推广应用。Objective To explore the clinical value of testing the level of immunoglobulin in the diagnosis and treatment of hepatitis B patients.Methods From January 2019 to February 2021,80 patients with hepatitis B in the hospital were random selected as the study group(38 cases in the mild group and 42 cases in the severe group according to the severity of the disease),and 80 healthy people in the hospital for physical examination during the same period were selected as the routine group,all were tested for serum immunoglobulin,and the results of 3 groups were counted.Results After treatment,IgA(2.51±0.60)g/L,IgG(14.18±2.45)g/L,IgM(2.62±0.43)g/L,TBIL(159.42±20.17)μmol/L in the study group were higher than those in the routine group,PTA(38.74±6.87)% was lower than the routine group,the difference was statistically significant(t=11.235,12.043,9.088,56.794,28.332,P<0.05);before treatment,the severe group of IgA,IgG,IgM,TBIL and other indicators were(4.21±0.98)g/L,(20.17±1.84)g/L,(3.11±0.92)g/L,(350.20±70.15)μmol/L,all higher than the mild group,PTA(26.10±4.52)% lower than the mild group,the difference was statistically significant(t=5.844,9.989,2.996,12.783,15.955,P<0.05);after treatment,the severe group of IgA,IgG,IgM,TBIL,etc.indicators were(3.75±0.71)g/L,(17.02±1.38)g/L,(2.75±0.70)g/L,(328.17±65.28)μmol/L,all higher than the mild group,PTA(30.16±5.46)% was lower than the mild group,the difference was statistically significant(t=10.351,7.950,3.982,11.911,12.883,P<0.05).Conclusion By detecting the serum immunoglobulin level of hepatitis B patients,the disease can be effectively diagnosed,and the patient's condition can also be evaluated,which is suitable for in-depth clinical research and popularization and application.

关 键 词：乙肝 血清免疫球蛋白 病情评估 

分 类 号：R757[医药卫生—皮肤病学与性病学]