基于“毒-瘀”理论分析虫类药物治疗下肢动脉硬化闭塞症的临床研究  

A Clinical Study on Insect Drugs in Treatment of Patients with Lower Extremity Arteriosclerosis Obliterans Based on the Theory of"Poison-Stasis"

作　　者：张鹤[1] 张花平 张楠[3] 张凯[1] 李浩杰 ZHANG He;ZHANG Hua-ping;ZHANG Nan;ZHANG Kai(The Second Department of Vascular Surgery,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050051,China;Department of Critical Care Medicine,People's Hospital of Shijiazhuang City,Shijiazhuang 050000,China;Department of Vascular Surgery,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]石家庄市中医院脉管二科,石家庄050051 [2]石家庄市人民医院重症医学科,石家庄050000 [3]河北医科大学第二医院血管外科,石家庄050000 [4]不详

出　　处：《解放军医药杂志》2021年第10期109-112,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：河北省中医药管理局科研计划项目(2021257)。

摘　　要：目的从"毒-瘀"理论分析虫类药物治疗下肢动脉硬化闭塞症(ASO)的临床效果及安全性。方法选取2020年1月—2021年1月收治的ASO 90例。按治疗方法分为观察组和对照组,每组45例。观察组给予基础治疗联合贝前列素钠片和虫类药物,对照组给予基础治疗联合贝前列素钠片,均治疗4周。比较2组治疗后临床症状、血液流变学、踝肱指数(ABI)、炎性因子[超敏C反应蛋白(hs-CRP)、白细胞介素-1(IL-1)及IL-6]及不良反应发生情况。结果观察组临床总有效率高于对照组(P<0.05)。与治疗前比较,2组治疗后ABI上升,血液黏度及hs-CRP、IL-1、IL-6水平下降,且观察组上述指标变化较对照组显著(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论基于"毒-瘀"理论的虫类药物治疗ASO具有很好的临床疗效,可改善血液流变学,降低炎性因子水平,安全可靠。Objective To analyze clinical efficacy and safety of insect drugs in treatment of patients with lower extremity arteriosclerosis obliterans(LEASO)based on the theory of"poison-stasis".Methods A total of 90 LEASO patients admitted between January 2020 and January 2021 were selected and divided into control group(n=45)and observation group(n=45)according to different therapeutic methods.Observation group was treated with basic treatment combined with Beraprost Sodium Tablets and insect drugs,while control group was treated with basic treatment combined with Beraprost Sodium Tablets.Both groups were treated for 4 weeks.Clinical symptoms,hemorheology,ankle-brachial index(ABI),inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),interleukin-1(IL-1)and interleukin-6(IL-6)]and incidence rate of adverse reactions were compared between two groups.Results The total effective rate in observation group was significantly higher than that in control group(P<0.05).After treatment,ABI values were significantly increased,while levels of blood viscosity and hs-CRP,Il-1 and IL-6 were significantly decreased compared with those before treatment in two groups,and changes of the above indicators in observation group were more significant than those in control group(P<0.05).No significant difference was found in incidence rate of adverse reactions between two groups(P>0.05).Conclusion Insect drugs based on the theory of"poison-stasis"may achieve good clinical efficacy improve hemorheology and reduce levels of inflammatory factors with good safety in treatment of patients with LEASO.

关 键 词：下肢动脉硬化闭塞症 毒-瘀理论 虫类药物 血液流变学 C反应蛋白 白细胞介素-1 白细胞介素-6 

分 类 号：R543.5[医药卫生—心血管疾病]