红花黄色素注射液辅助治疗非ST段抬高型心肌梗死患者的临床疗效及其对血小板聚集率、血栓弹力图指标的影响  

Clinical Effect of Safflower Yellow Injection in the Treatment of Patients with Non-ST Segment Elevation Myocardial Infarction and Its Impact on Platelet Aggregation Rate and Thromboelastogram Indexes

作　　者：马俊林 朱从飞[2] 刘泽超 MA Junlin;ZHU Congfei;LIU Zechao(Department of Cardiology,Huai'an NO.3 People's Hospital,Huai'an 223000,China;Department of Cardiology,Lianshui County People's Hospital,Huai'an 223400,China)

机构地区：[1]江苏省淮安市第三人民医院心内科,223000 [2]涟水县人民医院心内科,江苏省淮安市223400

出　　处：《实用心脑肺血管病杂志》2021年第11期92-95,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：背景现代药理学研究表明,红花具有抗血小板作用。红花黄色素作为红花的主要成分,可用于抗血小板治疗,但其在非ST段抬高型心肌梗死(NSTEMI)中的抗血小板作用尚不明确。目的探讨红花黄色素注射液辅助治疗对NSTEMI患者血小板聚集率及血栓弹力图(TEG)指标的影响。方法选取2019年2月至2020年10月在淮安市第三人民医院心内科成功实施经皮冠状动脉介入治疗(PCI)的108例NSTEMI患者为研究对象,按照治疗方法不同将其分为对照组(n=56)和观察组(n=52)。PCI后,对照组患者给予常规治疗,观察组患者在常规治疗基础上加用红花黄色素注射液治疗,2周为1个疗程,两组均治疗1个疗程。比较两组PCI后1 d及PCI后14 d血小板聚集率和TEG指标〔最大振幅(MA),凝血反应时间(R),血凝块成形时间(K),凝血指数(CI)〕,临床疗效及治疗期间不良事件发生情况。结果PCI后14 d,两组患者血小板聚集率分别低于本组PCI后1 d(P<0.05);PCI后14 d,观察组患者血小板聚集率低于对照组(P<0.05)。PCI后14 d,观察组患者MA、CI低于对照组,R、K长于对照组(P<0.05)。观察组患者临床疗效优于对照组(P<0.05)。观察组患者治疗期间不良事件发生率为7.7%(4/52),低于对照组的21.4%(12/56)(P<0.05)。结论PCI后采用红花黄色素注射液辅助治疗能有效提高NSTEMI患者的临床疗效,降低患者血小板聚集率,改善TEG指标,进而改善血小板及纤溶系统功能,且安全性较高。Background Modern pharmacological studies show that safflower has antiplatelet effect. Safflower yellow,as the main component of safflower, can be used in antiplatelet therapy, but its antiplatelet effect on non-ST segment elevation myocardial infarction(NSTEMI) is not clear. Objective To explore the clinical effect of safflower yellow injection in the treatment of patients with NSTEMI and its impact on platelet aggregation rate and thromboelastogram(TEG) indexes. Methods A total of 108 patients with NSTEMI who successfully underwent percutaneous coronary intervention(PCI) in the Department of Cardiology of Huai’an NO.3 People’s Hospital from February 2019 to October 2020 were selected as the research objects. They were divided into control group(n=56) and observation group(n=52) according to different treatment methods. After PCI, the patients in the control group were given routine treatment, and the patients in the observation group were treated with safflower yellow injection on the basis of routine treatment. Two weeks was a course of treatment, and both groups were treated for one course of treatment. The platelet aggregation rate and TEG indexes [maximum amplitude(MA), reaction time(R), agulation time(K), coagulation index(CI) ] at 1 and 14 days after PCI, clinical efficacy and adverse events during treatment were compared between the two groups. Results At the 14 days after PCI, the platelet aggregation rate of the two groups was lower than that of the 1 day after PCI(P < 0.05);at the 14 days after PCI, the platelet aggregation rate in the observation group was lower than that in the control group(P < 0.05). At the 14 days after PCI, MA and CI in the observation group were lower than those in the control group, R and K were longer than those in the control group(P < 0.05). The clinical effect of the observation group was better than that of the control group(P < 0.05). The incidence of adverse events in the observation group was 7.7%(4/52), which was lower than 21.4%(12/56) in the control group(P < 0.

关 键 词：心肌梗死 非ST段抬高型心肌梗死 红花黄色素注射液 血小板聚集率 血栓弹力图 

分 类 号：R542.22[医药卫生—心血管疾病]