大戟脂有效部位及大戟二烯醇抗炎镇痛作用研究  

Study on the Anti-inflammatory and Analgesic Effects of the Effective Parts of Euphorbium resinifera and Euphol

作　　者：刘婧 刘燕 赵军 李亚杰 顾政一 LIU Jing;LIU Yan;ZHAO Jun;LI Yajie;GU Zhengyi(School of Pharmacy,Shihezi University,Shihezi 832000,China;Xinjiang Uygur Autonomous Region Institute of Medicine,Urumqi 830004,China;School of Pharmacy,Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]石河子大学药学院,石河子832000 [2]新疆维吾尔自治区药物研究所,乌鲁木齐830004 [3]新疆医科大学药学院,乌鲁木齐830011

出　　处：《医药导报》2021年第12期1665-1670,共6页Herald of Medicine

基　　金：国家重大新药创制科技重大专项资助项目(2018ZX09711001-001-004)。

摘　　要：目的考察大戟脂有效部位和大戟二烯醇的抗炎镇痛作用。方法取昆明种小鼠80只,随机分为8组,分别为大戟脂有效部位大、中、小(60,30,15 mg·kg^(-1))剂量组,大戟二烯醇大、中、小(30,15,7.5 mg·kg^(-1))剂量组,0.5%CMC-Na组和吲哚美辛组(10 mg·kg^(-1)),每组10只。通过二甲苯致小鼠耳肿胀法、毛细血管通透性实验和棉球肉芽肿实验,综合观察大戟脂有效部位和大戟二烯醇的抗炎作用;采用热板法、醋酸扭体法和福尔马林法,评价其镇痛作用。结果大戟脂有效部位和大戟二烯醇在三种炎症模型上均显示了一定的抗炎作用,同时表现出良好的镇痛作用,其中以大戟二烯醇高剂量组效果最佳。结论大戟脂有效部位和大戟二烯醇具有显著的抗炎镇痛作用,其中大戟二烯醇发挥主要作用。Objective To investigate the anti-inflammatory and analgesic effects of the effective parts from Euphorbium resinifera and euphol.Methods Eighty Kunming mice were selected and randomly divided into 8 groups,including the high,medium,and low(60,30,15 mg·kg^(-1))dose groups of the effective parts from Euphorbium resinifera,the high,medium,and low(30,15,7.5 mg·kg^(-1))dose groups of euphol,0.5%CMC-Na group,and indomethacin group(10 mg·kg^(-1)),with ten rats in each group.Through the xylene-induced ear swelling model,capillary permeability test and cotton ball granuloma test,the anti-inflammatory effects of the effective part from Euphorbium resinifera and euphol were observed.The analgesic effect was evaluated by using hot plate method,acetic acid writhing method and formalin method.Results The effective parts from Euphorbium resinifera and euphol showed certain anti-inflammatory effects on the three inflammatory models,and also had good analgesic effects.Among them,the high-dose group of euphol had the best effect.Conclusion The effective parts from Euphorbium resinifera and euphol have significant anti-inflammatory and analgesic effects,and euphol plays a major role.

关 键 词：大戟脂 有效部位 大戟二烯醇 抗炎镇痛 

分 类 号：R285.5[医药卫生—中药学] R965[医药卫生—中医学]