蛋白激酶C在疼痛及镇痛药物作用中的研究进展  

Research Progress of Protein Kinase C in Pain and Analgesic Drugs

作　　者：易小清 崔小娇 陈祝君 尹琪楠 苟梦秋 边原[1] YI Xiaoqing;CUI Xiaojiao;CHEN Zhujun;YIN Qinan;GOU Mengqiu;BIAN Yuan(Department of Pharmacy&Personalized Drug Therapy Key Laboratory of Sichuan Province,Sichuan Provincial People’s Hospital/Affiliated Hospital of University of Electronic Science and Technology of China,Sichuan Academy of Medical Sciences,Chengdu Sichuan 610072,China)

机构地区：[1]四川省医学科学院·四川省人民医院/电子科技大学附属医院药学部·个体化药物治疗四川省重点实验室,成都610072

出　　处：《医药导报》2021年第12期1699-1703,共5页Herald of Medicine

基　　金：国家临床药学重点专科建设项目资助项目(NO.30305030698);四川省人民医院院级科研基金临床研究及转化项目(2018LY09)。

摘　　要：蛋白激酶C(PKC)是一组丝氨酸/苏氨酸激酶,是细胞内一种重要的信号转导分子。PKC亚型PKCε、PKCα、PKCγ、PKCδ可调节离子通道和受体,参与疼痛的发生。PKC在不同疼痛类型中已有相关研究,包括镰状细胞疾病的慢性疼痛、椎间盘退变、慢性偏头痛、炎症性疼痛、癌性骨痛、神经病理性疼痛。常用的镇痛药物包括非甾体类抗炎药、阿片类药物、抗惊厥类药物等,有研究表明PKC与吗啡、瑞芬太尼、对乙酰氨基酚、帕瑞昔布、加巴喷丁、普瑞巴林等镇痛药物之间也存在相互影响。目前,PKC在疼痛中的研究较多,该文就PKC与疼痛和镇痛药物的关系进行综述,有望为治疗疼痛提供新思路,成为疼痛病理生理机制研究和疼痛治疗的分子靶标。Protein kinase C(PKC)is a group of serine/threonine kinases,which are important signal transduction molecules in cells.The PKCε,PKCα,PKCγ,and PKCδsubtypes of PKC kinases can regulate ion channels and receptors,which participate in the occurrence of pain.The PKC kinase has been studied in various types of pain,including chronic pain in sickle cell disease,disc degeneration,chronic migraine,inflammatory pain,cancerous bone pain,neuropathic pain,and so on.The commonly used analgesic drugs include non-steroidal anti-inflammatory drugs,opioids,anticonvulsant drugs,etc.Studies have shown that the PKC is associated with morphine,remifentanil,acetaminophen,parecoxib,gabapentin,pregabalin and other analgesics.At present,there are many studies on the application of the PKC kinase in pain.This article reports the relationship between PKC kinase and pain and analgesic drugs.It is expected to provide novel ideas for the treatment of pain and become drug targets for the study of the pathophysiological mechanism.

关 键 词：蛋白激酶C 疼痛 非甾体类抗炎药物 阿片类药物 抗惊厥类药物 

分 类 号：R95[医药卫生—药学]