血液透析患者带隧道带涤纶套导管相关性血流感染危险因素分析及预测模型构建与验证  

Analysis of risk factors and development of a predictive model for tunnel-cuffed catheter-related bloodstream infection in hemodialysis patients

作　　者：刘莉莉[1] 刘玉秋 仰欣 施雯 涂岩[1] 潘明明[1] 张晓良[1] LIU Li-li;LIU Yu-qiu;YANG Xin;SHI Wen;TU Yan;PAN Ming-ming;ZHANG Xiao-liang(Department of Nephrology,Zhongda Hospital,School of Medicine,Southeast University,Nanjing 210009,China)

机构地区：[1]东南大学附属中大医院肾脏科,东南大学医学院,南京210009

出　　处：《中国血液净化》2021年第11期773-777,共5页Chinese Journal of Blood Purification

基　　金：国家自然科学基金(81870497)。

摘　　要：目的探讨应用长期导管血液透析并发导管相关性血流感染的危险因素,并建立相关预测模型。方法回顾性分析长期静脉置管行血液透析的终末期肾病患者临床资料,对训练组患者并发导管相关性血流感染的危险因素进行Logistic回归分析,利用R语言建立预测模型,并通过验证组对模型预测性能进行验证。结果导管相关性血流感染的危险因素包括吸烟史、贫血、糖尿病,由此构建的预测模型在训练组和验证组中C指数分别为0.761和0.714。结论该模型能够有效筛选血液透析患者并发导管相关性血流感染的高危人群。Objective To explore the risk factors and to establish a predictive model for catheter-related bloodstream infection in hemodialysis patients with long-term intravenous catheters.Methods We retrospectively analyzed the clinical data of end-stage renal disease patients undergoing hemodialysis using long-term indwelling intravenous catheters.Logistic regression analysis was performed to detect the risk factors for catheter-related bloodstream infection in the training group.R-studio was used to create the predictive model,and performance of the model was examined in the validation group.Results Smoking history,anemia and diabetes were the risk factors for catheter-related bloodstream infections.The C-indices of the training group and validation group from the established predictive model were 0.761 and 0.714,respectively.Conclusion The predictive model we established can effectively find out the high-risk group of catheter-related bloodstream infection in hemodialysis patients using long-term tunnel-cuffed catheters.

关 键 词：血液透析 带隧道带涤纶套导管 导管相关性血流感染 危险因素 列线图模型 

分 类 号：R318.16[医药卫生—生物医学工程]