VEGF、LCN2、hs-CRP在老年冠心病患者冠状动脉侧支循环形成中的诊断价值及相关性  

Diagnostic Value and Correlation of VEGF,LCN2 and hs-CRP in the Formation of Coronary Artery Collateral Circulation in Elderly Patients with Coronary Heart Disease

作　　者：侯申岩 王鹏 HOU Shenyan;WANG Peng(Chaoyang Central Hospital,Chaoyang 122000,China;不详)

机构地区：[1]辽宁省朝阳市中心医院,辽宁朝阳122000 [2]辽宁省朝阳市朝阳县疾控中心

出　　处：《中国医学创新》2021年第29期129-132,共4页Medical Innovation of China

摘　　要：目的:分析血管内皮生长因子(VEGF)、脂质运载蛋白2(LCN2)、超敏C反应蛋白(hs-CRP)在老年冠心病患者中的诊断价值,并探讨其与冠状动脉侧支循环形成的相关性。方法:收集2020年6月-2021年5月本院收治的老年冠心病患者480例作为研究组,根据Retrop-Cohen分级分为侧支循环组250例和无侧支循环组230例,侧支循环组又分为循环良好组150例和循环不良组100例;同期收集体检中心健康体检者100例作为对照组。比较VEGF、LCN2、hs-CRP在各组的表达差异,分析其诊断价值,探讨其与冠状动脉侧支循环形成的相关性。结果:研究组VEGF、LCN2、hs-CRP均明显高于对照组(P<0.05);循环良好组VEGF、LCN2均明显高于循环不良组,hs-CRP明显低于循环不良组,差异均有统计学意义(P<0.05);VEGF、LCN2、hs-CRP对冠状动脉侧支循环是否良好的ROC曲线结果显示,联合诊断的AUC为0.861,灵敏度和特异度分别为81.6%、62.7%;Spearman相关性分析显示,VEGF、LCN2、hs-CRP与冠状动脉侧支循环分级均密切相关(P<0.05)。结论:血清VEGF、LCN2、hs-CRP水平与老年冠心病患者冠状动脉侧支循环形成密切相关,联合检测有助于病情的诊断和评估。Objective:To analyze the diagnostic value of vascular endothelial growth factor(VEGF),lipid carrier protein 2(LCN2)and hypersensitive C-reactive protein(hs-CRP)in elderly patients with coronary heart disease,and to explore the correlation between VEGF,LCN2,hs-CRP and the formation of coronary artery collateral circulation.Method:A total of 480 elderly patients with coronary heart disease admitted to our hospital from June 2020 to May 2021 were collected as the study group.According to Retrop-Cohen classification,they were divided intothe collateral circulation group(n=250)and the non-collateral circulation group(n=230),the collateral circulation group were further divided into the good circulation group(n=150)and the bad circulation group(n=100).At the same time,100 healthy subjects from the physical examination center were collected as the control group.The expression differences of VEGF,LCN2 and hs-CRP among the groups were compared,the diagnostic value was analyzed,and the correlation between VEGF,LCN2,hs-CRP and the formation of coronary artery collateral circulation were explored.Result:The levels of VEGF,LCN2 and hs-CRP in the study group were higher than those in the control group(P<0.05).The levels of VEGF and LCN2 in the good circulation group were significantly higher than those in the poor circulation group,and the level of hs-CRP was significantly lower than that in the poor circulation group,the differences were statistically significant(P<0.05).ROC curve results of whether VEGF,LCN2 and hs-CRP were good for coronary collateral circulation showed that the AUC of combined diagnosis was 0.861,and the sensitivity and specificity were 81.6%and 62.7%respectively.Spearman correlation showed that VEGF,LCN2 and hs-CRP were closely correlated with the grade of coronary collateral circulation(P<0.05).Conclusion:Serum VEGF,LCN2 and hs-CRP levels are closely related to the formation of coronary artery collateral circulation in elderly patients with coronary heart disease,and the combined detection is helpful for

关 键 词：老年 冠心病 血管内皮生长因子 脂质运载蛋白2 超敏C反应蛋白 侧支循环 

分 类 号：R541.4[医药卫生—心血管疾病]