大株红景天注射液与阿托伐他汀联合治疗对冠心病患者血液流变学等指标的影响  

The effect of sofren injection combined with atorvastatin on hemorheology indicators in patients with coronary heart disease

作　　者：侯昊林 HOU Hao-lin(Dadong District People’s Hospital,Shenyang 110041,China)

机构地区：[1]沈阳市大东区人民医院,110041

出　　处：《中国现代药物应用》2021年第21期28-30,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析对冠心病患者使用大株红景天注射液与阿托伐他汀联合治疗的效果以及对血液流变学等指标的影响。方法34例冠心病患者,随机分为研究组及对照组,每组17例。研究组采用大株红景天注射液与阿托伐他汀联合治疗,对照组采用阿托伐他汀治疗。对比两组的治疗效果、心功能指标[左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)]、血液流变学指标[红细胞沉降率(ESR)、纤维蛋白原(FIB)、血浆粘度、全血粘度]、血脂指标[低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)]。结果研究组LVEDD(52.43±1.03)mm、LVESD(42.51±1.33)mm短于对照组的(54.88±1.08)、(45.26±1.85)mm,LVEF(57.36±1.16)%高于对照组的(48.73±1.84)%,差异有统计学意义(P<0.05)。治疗后,研究组全血粘度、ESR、FIB、血浆粘度分别为(4.12±0.26)mPa·s、(14.06±4.02)mm/h、(3.31±0.42)g/L、(1.27±0.09)mPa·s,均低于对照组的(5.03±0.43)mPa·s、(23.18±3.84)mm/h、(3.95±0.54)g/L、(1.91±0.11)mPa·s,差异有统计学意义(P<0.05)。研究组LDL-C、TC、TG分别为(1.78±0.31)、(4.08±0.52)、(1.25±0.09)mmol/L,低于对照组(3.16±0.41)、(5.17±1.34)、(2.06±0.22)mmol/L;HDL-C为(1.99±0.43)mmol/L,高于对照组的(1.56±0.38)mmol/L,差异有统计学意义(P<0.05)。研究组的治疗总有效率94.12%高于对照组的64.71%,差异有统计学意义(P<0.05)。结论对冠心病患者使用大株红景天注射液与阿托伐他汀联合治疗效果显著,能有效改善患者心功能指标、血液流变学指标及血脂指标,具有临床应用价值。Objective To analyze the effect of sofren injection combined with atorvastatin on patients with coronary heart disease,and its influence on hemorheology indicators.Methods A total of 34 patients with coronary heart disease were randomly divided into research group and control group,with 17 cases in each group.The research group was treated with sofren injection and atorvastatin,and the control group was treated with atorvastatin.Both groups were compared in terms of therapeutic effect,cardiac function indexes[left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),left ventricular ejection fraction(LVEF)],hemorheology indexes[erythrocyte sedimentation rate(ESR)),fibrinogen(FIB),plasma viscosity,whole blood viscosity],blood lipid indexes[low density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triglycerides(TG),high density lipoprotein cholesterol(HDL-C)].Results LVEDD(52.43±1.03)mm and LVESD(42.51±1.33)mm of the research group were shorter than(54.88±1.08)and(45.26±1.85)mm of the control group,and LVEF(57.36±1.16)%was higher than(48.73±1.84)%of the control group.All the differences were statistically significant(P<0.05).After treatment,the whole blood viscosity,ESR,FIB and plasma viscosity of the research group were(4.12±0.26)mPa·s,(14.06±4.02)mm/h,(3.31±0.42)g/L,(1.27±0.09)mPa·s,which were lower than(5.03±0.43)mPa·s,(23.18±3.84)mm/h,(3.95±0.54)g/L,(1.91±0.11)mPa·s of the control group,and the difference was statistically significant(P<0.05).LDL-C,TC,and TG of the research group were(1.78±0.31),(4.08±0.52)and(1.25±0.09)mmol/L,which were lower than(3.16±0.41),(5.17±1.34)and(2.06±0.22)mmol/L of the control group,and HDL-C(1.99±0.43)mmol/L was higher than(1.56±0.38)mmol/L of the control group.All the differences were statistically significant(P<0.05).The total effective rate of treatment 94.12%in the research group was higher than 64.71%in the control group,and the difference was statistically significant(P<0.05).Conclusion Sofren injection in co

关 键 词：冠心病 大株红景天注射液 阿托伐他汀 血液流变学指标 治疗效果 

分 类 号：R541.4[医药卫生—心血管疾病]