前列地尔联合依那普利叶酸对高血压肾病患者动脉弹性的影响分析  

Effect of alprostatil combined with enalapril and folic acid on arterial elasticity in patients with hypertensive nephropathy

作　　者：马斌[1] 张月兰[2] MA Bin;ZHANG Yue-lan(Department of Cardiology,Shenyang Ninth People’s Hospital,Shenyang 110024,China)

机构地区：[1]沈阳市第九人民医院心血管内科,110024 [2]中国医科大学附属一院心血管内科,110024

出　　处：《中国现代药物应用》2021年第21期144-146,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析前列地尔联合依那普利叶酸对高血压肾病患者动脉弹性的影响。方法92例高血压肾病患者,随机分为对照组和观察组,各46例。对照组接受前列地尔治疗,观察组接受前列地尔联合依那普利叶酸治疗。比较两组患者动脉弹性指标、肾功能指标及不良反应发生情况。结果治疗前,两组大动脉弹性指数(C1)、小动脉弹性指数(C2)及血管超负荷指数(VOI)比较,差异无统计学意义(P>0.05);治疗后,观察组C1(14.89±1.20)ml/mm Hg×10、C2(6.25±0.84)×100均大于对照组的(11.54±1.28)ml/mm Hg×10、(4.52±0.41)ml/mm Hg×100,VOI(10.25±1.68)小于对照组的(17.68±1.52),差异具有统计学意义(P<0.05)。治疗前,两组24 h尿蛋白、血清尿素氮(BUN)及血清肌酐(Scr)水平比较,差异无统计学意义(P>0.05);治疗后,观察组24 h尿蛋白、Scr及BUN水平均低于对照组,差异具有统计学意义(P<0.05)。观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论对高血压肾病患者应用前列地尔联合依那普利叶酸治疗,不仅可改善动脉弹性同时也可提升肾功能,联合治疗时也无头痛和恶心等不良反应,有临床推广价值。Objective To analyze the effect of alprostatil combined with enalapril and folic acid on arterial elasticity in patients with hypertensive nephropathy.Methods A total of 92 patients with hypertensive nephropathy were randomly divided into control group and observation group,each with 46 cases.The control group received alprostadil for treatment,and the observation group received alprostadil combined with enalapril and folic acid for treatment.The arterial elasticity index,renal function index and the occurrence of adverse reactions were compared between the two groups.Results Before treatment,there was no statistically significant difference between the two groups of large artery elasticity index(C1),small artery elasticity index(C2)and vascular overload index(VOI)(P>0.05).After treatment,C1(14.89±1.20)ml/mm Hg×10 and C2(6.25±0.84)×100 of the observation group were greater than(11.54±1.28)ml/mm Hg×10,(4.52±0.41)ml/mm Hg×100 of the control group,and VOI(10.25±1.68)was less than(17.68±1.52)of the control group.All the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the levels of 24 h urine protein,blood urea nitrogen(BUN)and serum creatinine(Scr)between the two groups(P>0.05).After treatment,the 24 h urine protein,Scr and BUN levels of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion Alprostatil in combination with enalapril and folic acid for patients with hypertensive nephropathy can not only improve arterial elasticity but also enhance renal function,and there are no adverse effects such as headache and nausea during combined therapy,which has the value of clinical promotion.

关 键 词：前列地尔 依那普利叶酸 高血压肾病 动脉弹性 

分 类 号：R544.1[医药卫生—心血管疾病] R692[医药卫生—内科学]