沈阳市某医院收治的23490例疑似呼吸道感染患者外周血常见呼吸道病毒IgM抗体检测结果分析  

Analysis of detection results of common respiratory virus IgM antibody in peripheral blood of 23490 pa⁃tients with suspected respiratory infection admitted to a hospital in Shenyang

作　　者：周霞[1] 张浩[1] 尚丹[1] 何丽[1] ZHOU Xia;ZHANG Hao;SHANG Dan;HE Li(Clinical Laboratory,The Fourth Affiliated Hospital of China Medical University,Shenyang 110032,China)

机构地区：[1]中国医科大学附属第四医院检验科,沈阳110032

出　　处：《山东医药》2021年第30期34-38,共5页Shandong Medical Journal

摘　　要：目的探讨2017年—2020年各年度沈阳地区呼吸道病毒的流行特征,为临床诊疗提供依据。方法选择2017年—2020年在中国医科大学附属第四医院就诊的疑似呼吸道感染患者23490例,采集患者外周血,采用EILSA法检测血清A型流感病毒(AIV)、B型流感病毒(BIV)、副型流感病毒(PIV)、腺病毒(ADV)、柯萨奇病毒(COX)、人类巨细胞病毒(HCMV)、呼吸道合胞病毒(RSV)、EB病毒壳抗原(VCA)IgM抗体。收集患者临床资料,分析呼吸道病毒的流行病学特征。结果2017年—2020年间23490例患者中检出呼吸道病毒IgM抗体阳性5750例(24.49%,5750/23490)。PIV、COX、RSV、BIV、ADV、VCA、HCMV、AIV IgM抗体阳性率分别为7.26%(1706/23490)、4.01%(942/23490)、3.90%(916/23490)、3.52%(826/23490)、2.93%(688/23490)、1.76%(413/23490)、1.03%(241/23490)、0%(18/23490)。2017、2018、2019、2020年患者呼吸道病毒IgM抗体阳性率分别为24.16%(1495/6189)、29.09%(1909/6563)、22.98%(1663/7238)及19.51%(683/3500),两两比较,P均<0.05;不同年份间患者呼吸道病毒IgM抗体(AIV除外)阳性率比较,P均<0.05。男、女患者呼吸道病毒IgM抗体阳性率分别为24.14%(3035/12570)、25.3%(2763/10920),二者比较,P<0.05;但是单病毒IgM抗体阳性率比较,差异无统计学意义。0~≤3岁、4~≤6岁、6~≤18岁、19~≤65岁及65~≤105岁患者呼吸道病毒IgM抗体阳性率分别为16.36%(552/3375)、17.28%(345/1997)、18.08%(234/1296)、25.74%(2370/9209)、29.53%(2248/7613)。成年(年龄≥18岁)患者比未成年(年龄<18岁)患者呼吸道病毒IgM抗体阳性率高(P均<0.05)。且不同年龄层的易感病毒存在差异。春、夏、秋、冬季患者呼吸道病毒IgM抗体阳性率分别为25.78%(1448/5617)、26.2%(1335/5096)、22.4%(1289/5821)、24.2%(1676/6926);不同季节患者BIV、PIV、HCMV、RSVIgM抗体阳性率存在差异,P均<0.05。结论2017年—2020年沈阳地区门诊/住院患者呼吸道病毒感染的阳性率仍较高。沈阳地区门诊/住院患�Objective To investigate the epidemiological characteristics of respiratory virus in Shenyang from 2017 to 2020,and to provide evidence for clinical diagnosis and treatment.Methods A total of 23490 patients with suspected respiratory tract infection admitted to the Fourth Affiliated Hospital of China Medical University from 2017 to 2020 were selected and their peripheral blood was collected.EILSA was used to detect IgM antibodies to influenza A virus(AIV),influenza B virus(BIV),parainfluenza virus(PIV),adenovirus(ADV),Coxsackie virus(COX),human cytomegalovirus(HCMV),respiratory syncytial virus(RSV),and Epstein-Barr virus shell antigen(VCA).Clinical data of patients were collected to analyze the epidemiological characteristics of respiratory virus.Results From 2017 to 2020,5750(24.49%,5750/23490)positive respiratory virus IgM antibodies were detected in 23490 patients from 2017 to 2020.The positive rates of the IgM antibodies to PIV,COX,RSV,BIV,ADV,VCA,HCMV and AIV were 7.26%(1706/23490),4.01%(942/23490),3.90%(916/23490),3.52%(826/23490),2.93%(688/23490),1.76%(413/23490),1.03%(241/23490),and 0%(18/23490),respectively.The positive rates of the IgM antibodies to respiratory virus were 24.16%(1495/6189),29.09%(1909/6563),22.98%(1663/7238)and 19.51%(683/3500),in 2017,2018,2019,and 2020,respectively,with statistically significant differences(all P<0.05).There were statistically significant differences in the positive rates of the IgM antibodies to respiratory virus(except AIV)between patients from different years(all P<0.05).The positive rates of the IgM antibodies to respiratory virus were 24.14%(3035/12570)and 25.3%(2763/10920),in male and female patients,respectively(both P<0.05).However,there was no significant difference in the positive rate of each IgM antibody.The positive rates of the IgM antibodies to respiratory virus were 16.36%(552/3375),17.28%(345/1997),18.08%(234/1296),25.74%(2370/9209),and 29.53%(2248/7613)in patients of 0–≤3 years old,4–≤6 years old,6–≤18 years old,19–≤65 years old,and 6

关 键 词：呼吸道病毒 A型流感病毒 B型流感病毒 副型流感病毒 腺病毒 柯萨奇病毒 人类巨细胞病毒 呼吸道合胞病毒 EB病毒 呼吸道感染 病毒感染 

分 类 号：R56[医药卫生—呼吸系统]