早期药物干预在妊娠期甲状腺功能减退症患者中的应用效果  

Application effect of early drug intervention in patients with hypothyroidism during pregnancy

作　　者：李海滨 张梅 LI Haibin;ZHANG Mei(Qishan County Hospital,Baoji 722400,China)

机构地区：[1]岐山县医院,陕西宝鸡722400

出　　处：《临床医学研究与实践》2021年第33期100-102,共3页Clinical Research and Practice

摘　　要：目的探讨早期药物干预在妊娠期甲状腺功能减退症患者中的应用效果。方法选取2017年2月至2020年2月岐山县医院收治的60例妊娠期甲状腺功能减退症患者作为研究对象,采用计算机随机化法将其分为对照组和试验组,每组30例。对照组给予常规干预,试验组在此基础上给予早期药物干预。比较两组的干预效果。结果干预后,两组的TSH水平均降低,FT3、FT4水平均升高,且试验组优于对照组(P<0.05)。试验组的糖代谢异常、肝内胆汁淤积、妊娠期高血压发生率均低于对照组(P<0.05)。试验组的低体重儿、新生儿窒息、早产、先兆子痫、流产、剖宫产发生率均低于对照组(P<0.05)。试验组婴儿的PDI、MDI评分均高于对照组(P<0.05)。结论早期药物干预应用于妊娠期甲状腺功能减退患者症中的效果显著,可改善患者的甲状腺功能指标,降低并发症发生率,改善妊娠结局,促进婴儿更好地生长发育。Objective To explore the application effect of early drug intervention in patients with hypothyroidism during pregnancy.Methods A total of 60 patients with hypothyroidism during pregnancy admitted in Qishan county hospital from February 2017 to February 2020 were selected as the research objects.The patients were divided into control group and experimental group by computer randomization,with 30 cases in each group.The control group was given routine intervention,and the experimental group was given early drug intervention on this basis.The intervention effects of the two groups were compared.Results After intervention,the level of TSH decreased and the levels of FT3 and FT4 increased in the two groups,and those in the experimental group were better than the control group(P<0.05).The incidences of abnormal glucose metabolism,intrahepatic cholestasis and gestational hypertension in the experimental group were lower than those in the control group(P<0.05).The incidences of low birth weight infants,neonatal asphyxia,preterm delivery,preeclampsia,abortion and cesarean section in the experimental group were lower than those in the control group(P<0.05).The scores of PDI and MDI of infants in the experimental group were higher than those in the control group(P<0.05).Conclusion Early drug intervention applied in patients with hypothyroidism during pregnancy has significant effect.It can improve the indexes of thyroid function,reduce the incidence of complications,ameliorate pregnancy outcome and promote the better growth and development of infants.

关 键 词：妊娠期甲状腺功能减退症 早期药物干预 不良妊娠结局 

分 类 号：R72[医药卫生—儿科]