2-苯甲酰亚胺基-4-苯基-4-羟基-3-(乙酸甲酯基)噻唑烷的合成及表征  

The Synthesis and Characterization of 2-Benzoylimino-3-(2-methoxy-2-oxoethyl)-4-hydroxy-4-phenylthiazolidine

作　　者：袁庆甲 张玲 沙峻岭 唐晓媛 刘真 支三军[1] YUAN Qing-jia;ZHANG Ling;SHA Jun-ling;TANG Xiao-yuan;LIU Zhen;ZHI San-jun(School of Chemistry and Chemical Engineering,Huaiyin Normal University,Huaian Jiangsu 223300,China)

机构地区：[1]淮阴师范学院化学化工学院,江苏淮安223300

出　　处：《淮阴师范学院学报（自然科学版）》2021年第4期307-310,共4页Journal of Huaiyin Teachers College;Natural Science Edition

基　　金：江苏省高校大学生创新创业训练计划项目(202018005XJ)。

摘　　要：研究了在三乙胺的存在下,1-苯甲酰基-3-(乙酸甲酯基)硫脲与w-溴代苯乙酮的成环反应,在30℃的丙酮溶液中反应3 h,以91.7%的收率得到目标化合物2-苯甲酰亚胺基-4-苯基-4-羟基-3-(乙酸甲酯基)噻唑烷.通过^(1)H NMR、^(13)C NMR等技术手段对目标化合物的结构进行了表征.在化合物的1H NMR图谱中观察到环内、环外的同碳H质子耦合现象.The cyclization reaction of methyl(3-benzoylthioureido)acetate and 2-bromoacetophenone was introduced with triethylamine as catalyst in acetone at 30℃.The product 2-benzoylimino-3-(2-methoxy-2-oxoethyl)-4-hydroxy-4-phenylthiazolidine was obtained in yield of 91.7%,and the characterization was carried out with ^(1)H NMR and ^(13)C NMR.The magnetic coupled phenomenon of the two hydrogen atoms on same carbon atoms in the molecule was founded.

关 键 词：2-苯甲酰亚胺基-3-乙酸甲酯氨基-4-苯基-4-羟基噻唑烷 1-苯甲酰基-3-(乙酸甲酯基)硫脲 w-溴苯乙酮 成环反应 

分 类 号：O621.13[理学—有机化学]