透明质酸纳米材料在荧光/光声成像和光疗中的应用  

Applications of Hyaluronic Acid Nanomaterials in Fluorescence/Photoacoustic Imaging and Phototherapy

作　　者：潘立祥 黄艳琴[1] 盛况 张瑞[1,3] 范曲立[1] 黄维[1,2] Lixiang Pan;Yanqin Huang;Kuang Sheng;Rui Zhang;Quli Fan;Wei Huang(State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM),Nanjing University of Posts&Telecommunications,Nanjing 210023,China;Shaanxi Institute of Flexible Electronics(SIFE),Northwestern Polytechnical University(NPU),Xi'an 710072,China;Department of Ophthalmology,Zhongda Hospital,Southeast University,Nanjing 210009,China)

机构地区：[1]南京邮电大学有机电子与信息显示国家重点实验室信息材料与纳米技术研究院,南京210023 [2]西北工业大学柔性电子研究院,西安710072 [3]东南大学附属中大医院眼科,南京210009

出　　处：《化学学报》2021年第9期1097-1106,共10页Acta Chimica Sinica

基　　金：教育部创新团队(IRT1148);江苏高校优势学科建设工程资助项目;先进生物与化学制造国家协同创新中心;有机电子与信息显示国家重点实验室开放研究基金资助课题资助。

摘　　要：荧光/光声成像和光疗技术的生物医学应用引起了人们越来越多的关注,然而很多荧光/光声造影剂存在生物相容性较差,缺乏肿瘤靶向性,信噪比较低,功能单一等共性问题,严重限制其诊疗应用.透明质酸具有优异的生物相容性和主动肿瘤靶向性,可被透明质酸酶降解,并且易于化学修饰和实现多种超分子弱相互作用力协同工作.因此,人们将透明质酸与荧光/光声造影剂结合制备纳米材料,使其在细胞乃至活体的标记性能和治疗效果获得了很大的改善.本文综述了将两类物质结合制备纳米材料的方法,着重阐述了纳米材料的结构与性能关系,为其未来设计和开发提供了指导,最后对存在的主要问题以及未来的重要研究方向进行了分析和展望.The biomedical applications of fluorescence/photoacoustic imaging and phototherapy have attracted more and more attention. However, many fluorescent/photoacoustic contrast agents have some common problems, such as poor biocompatibility, lack of tumor targeting, low signal-to-noise ratio, single function and so on, which seriously limit their application in diagnosis and treatment. Hyaluronic acid(HA) exhibits excellent biocompatibility and active tumor targeting, can be degraded by hyaluronidase, and is easy to be chemically modified and realize the cooperation of a variety of supramolecular weak interactions. Therefore, HA has been combined with fluorescent/photoacoustic contrast agents to prepare nanomaterials, which greatly improves the labeling performance and therapeutic effects in cells and even in vivo. In this paper, the preparation methods of nanomaterials by combining these two kinds of materials are reviewed, and the relationships between the structure and performance of nanomaterials are emphasized, which provides guidance for their future design and development. Finally, the main problems and important research directions in the future are analyzed and prospected.

关 键 词：透明质酸 荧光成像 光声成像 光热治疗 光动力治疗 

分 类 号：R318.08[医药卫生—生物医学工程] R730[医药卫生—基础医学] TB383.1[一般工业技术—材料科学与工程]