口服单种降糖药治疗的2型糖尿病患者高尿酸血症的影响因素  

The influencing factors of hyperuricemia in patients with type 2 diabetes treated with single oral antidiabetic drug

作　　者：田利华 赵香君 于红蕾 TIAN Li-hua;ZHAO Xiang-jun;YU Hong-lei(Department of Endocrinology, Qinhuangdao Military Hospital, Hebei Province, Qinhuangdao 066001, China)

机构地区：[1]河北省秦皇岛军工医院内分泌科,河北秦皇岛066001

出　　处：《河北医科大学学报》2021年第11期1261-1265,1297,共6页Journal of Hebei Medical University

摘　　要：目的探讨口服单种降糖药物的2型糖尿病(type 2 diabetes mellitus,T2DM)患者高尿酸血症(hyperuricemia,HUA)的影响因素。方法选取秦皇岛军工医院内分泌科门诊就诊的、口服单种降糖药治疗的T2DM患者共912例,根据血尿酸(serum uric acid,SUA)水平分为正常血尿酸组(normal uric acid,NUA)组(n=741)和HUA组(n=171)。比较各组糖脂代谢指标及口服降糖药物的使用情况;分析T2DM患者发生HUA的影响因素。结果T2DM患者中HUA的发生率为18.8%(171/912);与NUA组相比,HUA组总胆固醇(total cholesterol,TC)水平升高,且男性、HUA家族史、使用格列喹酮的比例升高(P<0.05或P<0.001),使用达格列净的比例降低(P<0.001);多因素Logistic回归分析显示使用达格列净(OR=0.414,95%CI:0.205~0.848)是T2DM患者HUA的保护因素,男性(OR=2.033,95%CI:1.054~3.921)、HUA家族史(OR=9.631,95%CI:4.1131~22.452)是T2DM患者HUA的危险因素。结论合并HUA的口服单药降糖治疗的T2DM患者可能与其男性性别、HUA家族史有关,可能具有较高水平的TC;使用达格列净可能降低这类患者罹患HUA的风险。Objective To investigate the influencing factors of hyperuricemia(HUA)in patients with type 2 diabetes mellitus(T2DM)treated with single oral antidiabetic drug.Methods A total of 912 patients taking single oral antidiabetic drug in the Department of Endocrinology,Qinhuangdao Military Hospital were selected and divided into normal uric acid group(NUA group,n=741)and HUA group(n=171)according to SUA level.The indexes of glucose and lipid metabolism and the use of oral antidiabetic drug were compared in each group,and the influencing factors of HUA in T2DM patients were analyzed.Results The incidence of HUA in T2DM patients was 18.8%(171/912).Compared with NUA group,the level of total cholesterol(TC)in HUA group was higher,the proportion of male,family history of HUA,and the use of Gliquidone were increased(P<0.05 or P<0.001),and the proportion of using Dapagliflozin was lower(P<0.001).Multivariate Logistic regression analysis showed that the use of Dapagliflozin(OR=0.414,95%CI:0.205-0.848)was the protective factor of HUA in T2DM patients,while male(OR=2.033,95%CI:1.054-3.921)and family history of HUA(OR=9.631,95%CI:4.113-22.452)were risk factors for HUA in T2DM patients.Conclusion The T2DM patients with HUA treated with single oral antidiabetic drug may be related to their male gender and family history of HUA,and may have a higher level of TC.The use of Dapagliflozin may reduce the risk of HUA in such patients.

关 键 词：糖尿病 2型 高尿酸血症 危险因素 

分 类 号：R587[医药卫生—内分泌]