关节软骨细胞周围透明质酸产生、转化和功能特征  

Hyaluronic acid around articular chondrocytes: production, transformation and function characteristics

作　　者：许磊 韩晓强[2] 张锦涛 孙海飚[2] Xu Lei;Han Xiaoqiang;Zhang Jintao;Sun Haibiao(The First Clinical College of Shanxi Medical University,Taiyuan 030001,Shanxi Province,China;Department of Orthopedics,The First Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi Province,China)

机构地区：[1]山西医科大学第一临床医学院,山西省太原市030001 [2]山西医科大学第一医院骨科,山西省太原市030001

出　　处：《中国组织工程研究》2022年第5期768-773,共6页Chinese Journal of Tissue Engineering Research

基　　金：青年三晋学者特聘教授支持计划[晋财(2016)128-2],项目负责人:孙海飚。

摘　　要：背景:目前尚无关于关节软骨细胞周围透明质酸的代谢和功能等方面的综述。目的:全面总结透明质酸最新的定义及实验研究结果,为临床应用提供理论基础。方法:通过计算机检索中国知网、万方医学网、PubMed数据库中的相关文献,检索时间从建库截至2020年11月,检索中文主题词为"透明质酸、玻尿酸、透明质酸钠、玻璃酸钠、骨关节炎、软骨、软骨细胞",英文主题词为"hyaluronic acid,cartilage,osteoarthritis,sodium hyaluronate"。按入选标准筛选,最终对75篇文献进行归纳和总结。结果与结论:透明质酸在关节内,尤其是在软骨细胞及其周围基质中发挥多种作用。透明质酸为蛋白多糖集聚体提供基本支架,使其可承担部分软骨承重的作用;透明质酸与CD44形成的通路可以传递细胞与周围基质之间的信息;透明质酸与聚集蛋白聚糖的不断周转和更新可以增加软骨抵抗外界损伤的能力。外源性透明质酸制剂可以保护软骨,治疗骨关节炎和止痛,甚至可治疗骨转移癌。BACKGROUND: Up to date, there is still no review on the metabolism and function of hyaluronic acid around articular chondrocytes.OBJECTIVE: To summarize the latest definition and experimental results of hyaluronic acid, thereby providing theoretical basis for the clinical application of hyaluronic acid.METHODS: The relevant literatures in CNKI, WanFang, and PubMed databases were searched by computer from the establishment of the database to November 2020. The keywords were "hyaluronic acid, cartilage, sodium hyaluronate, osteoarthritis, cartilage, chondrocytes" in Chinese and English, respectively. Finally, 75 eligible articles were included for further analysis.RESULTS AND CONCLUSION: Hyaluronic acid plays a variety of roles in the joint, especially in chondrocytes and its surrounding matrix. Hyaluronic acid provides a basic scaffold for proteoglycan aggregates, which can bear part of the cartilage load-bearing function. The pathway formed by hyaluronic acid and CD44 can transmit the information between cells and the surrounding matrix. Continuous turnover and renewal of hyaluronic acid and aggrecan can increase the ability of cartilage to resist external damages. Exogenous hyaluronic acid can protect cartilage, treat osteoarthritis, relieve pain, and even treat bone metastases.

关 键 词：透明质酸 软骨 骨关节炎 软骨细胞 综述 玻璃酸钠 玻尿酸 透明质酸钠 

分 类 号：R446[医药卫生—诊断学] R496[医药卫生—临床医学]