大剂量阿司匹林致川崎病患儿急性肝功能衰竭1例分析  

One Case of Acute Liver Failure in Children with Kawasaki Disease Induced by High-dose Aspirin

作　　者：喻明丽 罗季 陈永刚 陈洁 彭江丽 YU Mingli;LUO Ji;CHEN Yonggang;CHEN Jie;PENG Jiangli(Department of Pharmacy,the Third People's Hospital of Kunming,Kunming Yunnan 650041,China)

机构地区：[1]昆明市第三人民医院药剂科,云南昆明650041

出　　处：《中国药物警戒》2021年第10期989-991,共3页Chinese Journal of Pharmacovigilance

摘　　要：目的提高临床使用大剂量阿司匹林的安全性。方法通过对1例川崎病患儿使用大剂量阿司匹林后出现严重肝衰竭的病例报道,结合国内外文献进行分析。结果本例患儿很可能是由阿斯匹林引起的肝损伤,阿司匹林引起药物肝损伤在临床中较为罕见,主要与使用剂量密切相关。结论对于川崎病患儿需要使用大剂量阿司匹林时,应密切监测患儿的肝功能及消化系统的反应,并应普及阿司匹林的血药浓度监测,以便预防阿司匹林引起严重肝损伤等药物不良反应。Objective To improve the safety of clinical use of high-dose aspirin. Methods One case of severe liver failure in a child with Kawasaki disease after using high-dose aspirin was reported and analyzed in combination with domestic and foreign literature. Results The patient was likely to suffer from aspirin-induced liver injury, which is rare in clinical practice and mainly related to the dosage. Conclusion When children with Kawasaki disease need to use large doses of aspirin, the liver function and related digestive system reactions should be closely monitored. Blood concentration monitoring of aspirin should be popularized to prevent such adverse drug reactions such as severe liver injury.

关 键 词：阿司匹林 肝损伤 药品不良反应 

分 类 号：R994.11[医药卫生—毒理学]