用4-溴苯乙酮无金属季鏻化甲基二苯基膦的研究  

Metal-Free Quaternization of Methyldiphenylphosphine with 4-Bromoacetophenone

作　　者：薛晶宇 黄文华 XUE Jingyu;HUANG Wenhua(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300354,China)

机构地区：[1]天津大学化工学院,天津300354

出　　处：《化学与生物工程》2021年第11期7-10,共4页Chemistry & Bioengineering

基　　金：国家自然科学基金项目(21272170)。

摘　　要：为进一步了解芳基溴无金属季鏻化的反应规律,以4-溴苯乙酮和甲基二苯基膦(MePPh_(2))为模型化合物,研究其在苯酚中回流生成(4-乙酰苯基)甲基二苯基溴化鏻的反应,通过1HNMR跟踪反应,分别考察了反应时间、原料配比和苯酚用量对(4-乙酰苯基)甲基二苯基溴化鏻收率的影响。结果表明,(4-乙酰苯基)甲基二苯基溴化鏻收率随反应时间的延长而升高,当反应时间为5 h,收率达到最高,进一步延长反应时间并不能提高(4-乙酰苯基)甲基二苯基溴化鏻收率;(4-乙酰苯基)甲基二苯基溴化鏻收率随n(MePPh_(2))∶n(4-溴苯乙酮)的增大总体呈下降趋势;(4-乙酰苯基)甲基二苯基溴化鏻收率随苯酚用量的增加而降低。In order to further understand the reaction rule of metal-free quaternization of aryl bromide,using 4-bromoacetophenone and methyldiphenylphosphine(MePPh_(2))as model compounds,we investigated their reaction in refluxing phenol to form(4-acetylphenyl)methyldiphenylphosphonium bromide,and the reaction was traced by 1HNMR.Moreover,we investigated the effects of reaction time,molar ratio of raw materials,and phenol dosage on the yield of(4-acetylphenyl)methyldiphenylphosphonium bromide.The results show that the yield of(4-acetylphenyl)methyldiphenylphosphonium bromide will increase with the increase of reaction time,which reaches the highest when the reaction time is 5 h,but will not increase with the further increase of reaction time.The yield of(4-acetylphenyl)methyldiphenylphosphonium bromide will generally decrease with the increase of n(MePPh_(2))∶n(4-bromoacetophenone),and will decrease with the increase of phenol dosage.

关 键 词：芳基季鏻盐 季鏻化 无金属 4-溴苯乙酮 甲基二苯基膦 

分 类 号：O627.51[理学—有机化学]