非空腹血脂与动脉粥样硬化性心血管疾病发生及预后关系的研究进展  

Progress on association of non-fasting lipid profiles with occurrence and prognosis of atherosclerotic cardiovascular disease

作　　者：程淇 黄雨晴[2] 冯颖青[2] CHENG Qi;HUANG Yu-Qing;FENG Ying-Qing(School of Medicine,South China University of Technology,Guangzhou 510006,China;Hypertension Research Laboratory,Guangdong Cardiovascular Institute,Guangdong Provincial People′s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China)

机构地区：[1]华南理工大学医学院,广州510006 [2]广东省医学科学院·广东省人民医院广东省心血管病研究所高血压研究室,广州510080

出　　处：《中华老年多器官疾病杂志》2021年第11期866-870,共5页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：广东省重点领域研发计划项目(2019B020227005);广东省基础与应用基础研究基金项目(2020A1515010738);广州市科技计划项目(201803040012)。

摘　　要：动脉粥样硬化性心血管疾病(ASCVD)是危害人类健康最主要的慢性非传染性疾病之一,尽管既往大量研究表明空腹血脂与ASCVD发生及其预后密切相关,但空腹血脂检测在临床上有一定的局限性。近年来研究发现,非空腹血脂对ASCVD的发生及预后也有重要作用,且相比空腹血脂,非空腹血脂检测能反映人体一天中大部分时间的血脂水平,更方便快捷。因此,本文就非空腹血脂的定义、优缺点、使用范围及其与ASCVD发生及预后关系的研究进展、致动脉粥样硬化的可能机制进行综述,以期为临床实践提供指导。Atherosclerotic cardiovascular disease(ASCVD)is one of the most important chronic noncontagious diseases that does harm to human health.Although lots of previous studies have reported that fasting lipid profiles are closely related to the occurrence and prognosis of ASCVD,fasting lipid test has some limitations in clinical practice.In recent years,evidence shows that non-fasting lipid profiles also play an important role in the occurrence and prognosis of ASCVD.Compared to fasting lipid test,non-fasting lipid test can reflect the blood lipid levels of human body at most of the time,more rapidly and conveniently.Therefore,this article reviews the definition,relative merits and scope of application of non-fasting lipid profiles,research progress of the relationship between the profiles and the occurrence and prognosis of ASCVD,and possible mechanism for atherosclerosis,in order to provide guidance in clinical practice.

关 键 词：动脉粥样硬化 心血管疾病 非空腹血脂 心血管风险 

分 类 号：R543.5[医药卫生—心血管疾病]