孟鲁司特钠咀嚼片联合盐酸氮卓斯汀鼻喷雾剂治疗儿童过敏性鼻炎疗效观察  

Efficacy of Montelukast Sodium Chewable Tablets Combined with Azelastine Hydrochloride Nasal Spray in the Treatment of Children with Allergic Rhinitis

作　　者：陈颖[1] 冯振华[2] 马萍萍[1] Chen Ying;Feng Zhenhua;Ma Pingping(Jiaozuo People’s Hospital,Henan Jiaozuo 454002,China;Jiaozuo Second People’s Hospital,Henan Jiaozuo 454150,China;不详)

机构地区：[1]焦作市人民医院,河南焦作454002 [2]焦作市第二人民医院,河南焦作454150

出　　处：《儿科药学杂志》2021年第11期15-18,共4页Journal of Pediatric Pharmacy

摘　　要：目的:探讨儿童过敏性鼻炎的治疗方法。方法:选择2018年1月至2019年9月焦作市人民医院门诊收治的单纯过敏性鼻炎患儿94例,采用随机数表法分为观察组48例和对照组46例。对照组给予盐酸氮卓斯汀鼻喷雾剂,观察组在对照组基础上给予孟鲁司特钠咀嚼片治疗。治疗前后对鼻部症状进行评分,测定血清免疫球蛋白E(IgE)、白细胞介素6(IL-6)、白细胞介素10(IL-10)、转化生长因子-β1(TGF-β1)水平,采用过敏性鼻炎相关生活质量问卷(RQLQ)评价患儿生活质量,评估疗效及安全性。结果:观察组总有效率为97.92%,高于对照组的82.61%(P<0.05)。治疗后两组患儿鼻塞、鼻痒、喷嚏、流涕等症状评分及IgE、IL-6、TGF-β1水平均降低,且观察组均低于对照组;IL-10水平均升高,且观察组高于对照组(P均<0.05)。治疗后观察组鼻部症状、眼部症状、非鼻部症状、情感、总体生活质量等维度评分均低于对照组(P均<0.05)。治疗期间对照组和观察组不良反应发生率分别为4.35%、8.33%(P>0.05)。结论:孟鲁司特钠咀嚼片联合盐酸氮卓斯汀鼻喷雾剂治疗儿童过敏性鼻炎效果较好,可改善临床症状及炎症反应,安全性较高。Objective: To probe into the treatment of allergic rhinitis in children. Methods: Totally 94 children with allergic rhinitis admitted into Jiaozuo People’s Hospital from Jan. 2018 to Sept. 2019 were extracted to be divided into 48 cases in the observation group and 46 cases in the control group via the random number table. The control group was given azelastine hydrochloride nasal spray for inhalation, while the observation group received montelukast sodium chewable tablets on basis of the control group. Nasal symptoms were recorded before and after treatment, and the levels of serum immunoglobulin E(IgE), interleukin-6(IL-6), interleukin-10(IL-10), transforming growth factor β1(TGF-β1) were determined. Rhinoconjunctivitis quality of life questionnaire(RQLQ) was used to evaluate the quality of life, efficacy and safety. Results: The total effective rate of the observation group was 97.92%, higher than that of the control group(82.61%, P<0.05). After treatment, the scores of symptoms such as nasal congestion, nasal itching, sneezing and runny nose, and the levels of IgE, IL-6 and TGF-β1 decreased in both groups, and the observation group was lower than the control group;the level of IL-10 increased in both groups, and the observation group was higher than the control group(P<0.05). The dimensional scores of nasal symptoms, ocular symptoms, non-nasal symptoms, emotions and overall quality of life in the observation group were lower than those in the control group after treatment(P<0.05). The incidences of adverse drug reactions in the control group and the observation group were respectively 4.35% and 8.33%(P>0.05). Conclusion: The efficacy of montelukast sodium chewable tablets combined with azelastine hydrochloride nasal spray in the treatment of children with allergic rhinitis is significant, which can improve the clinical symptoms and inflammatory response with higher safety.

关 键 词：过敏性鼻炎 儿童 孟鲁司特钠 盐酸氮卓斯汀 

分 类 号：R725.6[医药卫生—儿科]