类癌综合征和类癌性心脏病的诊疗新进展  

Diagnosis and Treatment of Carcinoid Syndrome and Carcinoid Heart Disease

作　　者：梁婷[1] 王慧[1] 彭瑛[1] LIANG Ting;WANG Hui;PENG Ying(Department of Cardiology,West China Hospital,Sichuan University,Chengdu 610041,Sichuan,China)

机构地区：[1]四川大学华西医院心内科,四川成都610041

出　　处：《心血管病学进展》2021年第11期965-967,977,共4页Advances in Cardiovascular Diseases

基　　金：四川省科技计划资助(2019YF0350)。

摘　　要：类癌较为罕见,在临床中容易被误诊,其衍生的类癌综合征可出现血管舒缩、胃肠道动力增高、支气管痉挛和类癌性心脏病的改变,后者主要表现为右心瓣膜(以三尖瓣多见)开闭功能受限。多模态心血管影像学在类癌性心脏病的诊断和预后评价中扮演了重要角色。放射性核素肽受体介导治疗靶向给药,通过降低血中激素水平可有效治疗类癌综合征,同时,经导管右心瓣膜置换术也在少数类癌性心脏病患者中进行了尝试。现就类癌综合征和类癌性心脏病的诊疗新进展进行综述,以期增强临床医生对该病的认识,提供更优化的治疗途径。Carcinoid is rare and easy to be misdiagnosed in clinical practice.Its derived carcinoid syndrome can appear changes in vasomotor contraction,increased gastrointestinal motility,bronchospasm and carcinoid heart disease.The latter is mainly characterized by limited opening and closing function of right heart valve(most commonly tricuspid valve).Multimodal cardiovascular imaging plays an important role in the diagnosis and prognosis of carcinoid heart disease.Radionuclide peptide receptor-mediated targeted therapy can effectively treat carcinoid syndrome by reducing the level of hormone in blood.At the same time,transcatheter right heart valve replacement has also been tried in a few patients with carcinoid heart disease.This paper reviews the new progress in the diagnosis and treatment of carcinoid syndrome and carcinoid heart disease,in order to enhance clinicians’understanding of the disease and provide more optimized treatment approaches.

关 键 词：类癌 类癌综合征 类癌性心脏病 

分 类 号：R541[医药卫生—心血管疾病] R730.6[医药卫生—内科学]