血清HbA HbF及G-6-PD水平与新生儿高胆红素血症的相关性分析  

Correlation Between Levels of Serum HbA HbF and G-6-PD and Neonatal Hyperbilirubinemia

作　　者：武秀梅 马英[1] 乔晓霞 董昌虎[2] 张红爱 汪利群[4] WU Xiumei;MA Ying;QIAO Xiaoxia(Xi'an Children's Hospital, Shaanxi Xi'an 710003, China)

机构地区：[1]陕西省西安市儿童医院新生儿科,陕西西安710003 [2]陕西中医药大学第二附属医院,陕西咸阳712000 [3]上海交通大学附属第一人民医院儿科,上海200085 [4]陕西省西安市儿童医院东区,陕西西安710032

出　　处：《河北医学》2021年第11期1773-1777,共5页Hebei Medicine

基　　金：陕西省中医药管理局中医药科研课题项目,(编号:JCMS066)。

摘　　要：目的:分析血清血红蛋白A(HbA)、血红蛋白F(HbF)及葡萄糖-6-磷酸脱氢酶(G-6-PD)水平与新生儿高胆红素血症的相关性。方法:选取我院新生儿科2017年2月至2020年2月收治的106例高胆红素血症新生儿,作为研究组,另选择同期医院106例正常新生儿作为对照组,根据高胆红素血症患儿病情将研究组新生儿分为轻度病情组(n=55)、中度病情组(n=31)和重度病情组(n=20),比较研究组和对照组新生儿血清HbA、HbF及G-6-PD水平,并分析血清HbA、HbF及G-6-PD水平与新生儿高胆红素血症的相关性。结果:研究组高胆红素血症患儿血清HbA、TBil水平明显高于对照组(P<0.05),血清HbF、G-6-PD水平明显低于对照组(P<0.05);重度病情组血清HbA水平高于轻度病情组和中度病情组(P<0.05),且中度病情组高于轻度病情组(P<0.05),重度病情组HbF水平低于轻度病情组和中度病情组(P<0.05),各组G-6-PD水平无明显差异(P>0.05);高胆红素血症患儿血清HbA水平与TBil水平呈正相关(P<0.05),HbF水平与TBil水平呈负相关(P<0.05),G-6-PD水平与TBil水平无明显相关性(P>0.05)。结论:高胆红素血症新生儿血清HbA水平较高,HbF、G-6-PD水平较低,且患儿病情程度与HbA、HbF水平有关,检测血清HbA、HbF水平有助于评估高胆红素血症新生儿病情。Objective:To analyze the correlation between levels of serum hemoglobin A(HbA),hemoglobin F(HbF)and glucose-6-phosphate dehydrogenase(G-6-PD)and neonatal hyperbilirubinemia.Methods:A total of 106 neonates with neonatal hyperbilirubinemia admitted to the pediatric department of the hospital from February 2017 to February 2020 were selected as study group,and 106 normal neonates in the hospital at the same period were selected as control group.The neonates in study group were divided into mild group(n=55),moderate group(n=31)and severe group(n=20)according to the disease conditions of children patients with hyperbilirubinemia.The levels of serum HbA,HbF and G-6-PD were compared between study group and control group,and the correlation between levels of serum HbA,HbF and G-6-PD and neonatal hyperbilirubinemia was analyzed.Results:The levels of serum HbA and TBil of hyperbilirubinemia children patients in study group were significantly higher than those in control group(P<0.05),and the levels of serum HbF and G-6-PD were significantly lower than those in control group(P<0.05).The level of serum HbA of severe group was higher than that of mild group and moderate group(P<0.05),and the level of moderate group was higher than that of mild group(P<0.05),and the HbF level of severe group was lower than that of mild group and moderate group(P<0.05),and there was no significant difference in the G-6-PD level in each group(P>0.05).Serum HbA level of children patients with hyperbilirubinemia was positively correlated with TBil level(P<0.05),and HbF level was negatively correlated with TBil level(P<0.05),and the G-6-PD level was not obviously correlated with TBil level(P>0.05).Conclusion:The level of serum HbA is higher and the levels of HbF and G-6-PD are lower among neonates with hyperbilirubinemia,and the disease severity of children patients is related to the levels of HbA and HbF.Detection of serum HbA and HbF levels is helpful to evaluate the disease severity of neonates with hyperbilirubinemia.

关 键 词：高胆红素血症 新生儿 血红蛋白A 血红蛋白F 葡萄糖-6-磷酸脱氢酶 

分 类 号：R72[医药卫生—儿科]