夫妻双方不同HBV感染状态对IVF/ICSI-ET治疗患者妊娠率和妊娠结局与母婴结局的影响  

Influence of different state of HBV infections of husband and wife on pregnancy rate,pregnancy outcomes and maternal-infant outcomes of patients treated by IVF/ICSI-ET

作　　者：陈素琴 石玉珊 俞丹凤 高思 罗杰 CHEN Su-qin;SHI Yu-shan;YU Dan-feng;GAO Si;LUO Jie(The First People′s Hospital of Hangzhou Lin′an District,Hangzhou,Zhejiang311300,China)

机构地区：[1]浙江杭州市临安区第一人民医院产科,浙江杭州311300

出　　处：《中华医院感染学杂志》2021年第19期3031-3035,共5页Chinese Journal of Nosocomiology

基　　金：杭州市医药卫生科技基金资助项目(OO20190014)。

摘　　要：目的研究夫妻双方不同乙型肝炎病毒(HBV)感染状态对体外受精/卵胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)治疗患者妊娠率和妊娠结局与母婴结局的影响。方法以2016年1月-2019年6月浙江省杭州市临安区第一人民医院接受IVF/ICSI-ET治疗的不孕夫妇临床资料为样本进行回顾性分析,其中HBV双方阳性组58对、男方阳性组47对、女方阳性组39对以及阴性组61对,比较各组基本资料、促排卵结果、胚胎发育及妊娠结局。结果各组年龄、女方体质量指数(BMI)、不孕年限、继发不孕比例、不孕病因及基础卵泡刺激素(FSH)等基本资料比较差异无统计学意义;各组促性腺激素释放激素短效激动剂(GnRH-a)疗程和剂量、FSH疗程和剂量、绒毛膜性腺激素(hCG)日雌二醇、hCG日子宫内膜厚度、取卵数量和胞浆内单精子注射(ICSI)占比等促排卵信息比较差异无统计学意义;夫妻双方阳性组双原核(2PN)受精率低于阴性组(P<0.05),各组受精率、卵裂率、正常卵裂率和优质胚胎率比较差异无统计学意义;各组胚胎着床率、妊娠率、自然流产率以及活产率比较差异无统计学意义;各组孕妇并发症和新生儿健康状况比较差异无统计学意义。结论HBV感染可能对IVF/ICSI-ET治疗造成一定影响,夫妻双方均阳性可导致双原核受精率明显降低,但对胚胎发育、妊娠结局和母婴健康无明显影响。OBJECTIVE To study the effects of different hepatitis B virus(HBV)infections of husband and wife on the pregnancy rate,pregnancy outcomes and maternal-infant outcomes of patients treated by in vitro fertilization/intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET).METHODS The clinical data of infertile couples who received IVF/ICSI-ET treatment in department of obstetrics of the First People′s Hospital of Hangzhou Lin′an District,Zhejiang Province between Jan.2016and Jun.2019were used as samples for retrospective analysis.Among them,there were 58pairs of HBV positive group,47pairs of male positive group,and 39pairs of female positive group and 61pairs of negative group.The basic information,ovulation induction results,embryonic development and pregnancy outcomes were compared among the groups.RESULTS There were no significant differences in the basic data such as age,female body mass index(BMI),years of infertility,proportion of secondary infertility,causes of infertility and basic FSH among the groups.There were no significant differences in the treatment course and dose of gonadotropin-releasing hormone short-acting agonist(GnRH-a),treatment course and dose of follicle stimulating hormone(FSH),estradiol at human chorionic gonadotropin(hCG)day,endometrial thickness at hCG day,number of retrieved eggs and proportion of intracytoplasmic sperm injection(ICSI).The fertilization rate of double pronucleus(2PN)in husband-wife positive group was significantly lower than that in negative group(P<0.05),and there were no significant differences in the fertilization rate,cleavage rate,normal cleavage rate and high-quality embryo rate in each group.There were no significant differences in the embryo implantation rate,clinical pregnancy rate,spontaneous abortion rate and live birth rate among the groups.There were no significant differences in the complications of pregnant women and health status of neonates among the groups.CONCLUSION HBV infection may have a certain impact on IVF/ICSI-ET treatment.Both spouses

关 键 词：体外受精 胚胎移植 乙型肝炎病毒 胚胎发育 妊娠结局 

分 类 号：R512.32[医药卫生—内科学]