药用耐盐性卡波姆树脂的合成工艺研究  

Synthesis of salt-tolerant carbomer resin for medicinal use

作　　者：龙杰凤 张杨[1] 赵才亮 王启文 LONG Jiefeng;ZHANG Yang;ZHAO Cailiang;WANG Qiwen(Kaili University,Kaili 556011,China)

机构地区：[1]凯里学院,贵州凯里556011

出　　处：《贵州科学》2021年第5期59-63,共5页Guizhou Science

基　　金：贵州省教育厅青年科技人才成长项目:黔东南苗药黄精的种质资源调查及其抑菌活性研究(黔教合KY字〔2019〕191);凯里学院“博士教授服务团”专项课题(BJFWT201909);国中医药办科技函〔2018〕132号;国中医药办科技函〔2019〕186号(HX201911-HX201914)。

摘　　要：目的:探索药用耐盐性卡波姆树脂工艺优化的最佳条件。方法:以正环己烷与乙酸乙酯作为混合溶剂合成药用耐盐性卡波姆树脂,对合成温度、单体配比、引发剂用量、交联剂用量进行单因素试验,通过最优的单因素条件进行正交试验,得到耐盐性卡波姆树脂合成的优化工艺。结果:耐盐性卡波姆树脂的最佳合成工艺为:丙烯酸单体(CAA)∶正环己烷∶乙酸乙酯∶增稠剂(SAB)∶引发剂B1(偶氮二异丁腈)∶交联剂B2(烯丙基季戊四醇醚)为1∶4.875∶1.625∶0.05∶0.005∶0.01,聚合反应8 h,反应温度65℃,反应浆料离心15 min,85℃干燥10 h,过筛得到白色、细腻、轻质的粉末卡波姆树脂产品。In this study the optimum conditions for the synthesis of salt-tolerant carbomer resin for medicinal use was determined.Salt-tolerant carbomer resin was synthesized by using n-cyclohexane and ethyl acetate as the mixed solvent.The synthesis temperature,monomer ratio,initiator dosage and crosslinking agent dosage were studied by single factor experiments.Then the optimal synthesis conditions of salt-tolerant carbomer resin were determined by orthogonal test.The optimal synthesis process was as follows:acrylic monomer(CAA)∶n-cyclohexane∶ethyl acetate∶thickener(SAB)∶initiator B1(azodiisobutyronitrile)∶crosslinking agent B2(allyl pentaerythritol ether)=1∶4.875∶1.625∶0.05∶0.005∶0.01;reacting at 65℃for 8 h;centrifuging the slurry obtained by the reaction for 15 min,then dring at 85℃for 10 h.After sieving,the white,fine and light powder of carbomer resin was obtained.

关 键 词：药用 卡波姆 工艺优化 正交试验 

分 类 号：R284.2[医药卫生—中药学]